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Details on Person Phosphorylated Stat3 Dissociates from Leptin Receptor

Class:Id	Reaction:2671877
_displayName	Phosphorylated Stat3 Dissociates from Leptin Receptor
_doRelease	TRUE
_timestamp	2013-10-26 10:17:45
authored	[InstanceEdit:2671737] May, B, 2012-11-24
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2671863] May, B, 2012-11-26
edited	[InstanceEdit:2671737] May, B, 2012-11-24
input	[Complex:2671870] Lep:p-Lepr:p-Jak2:p-Stat3 [plasma membrane] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2672268] Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice [LiteratureReference:2671754] Activation of downstream signals by the long form of the leptin receptor [LiteratureReference:2672232] Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines [LiteratureReference:2672272] Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130
modified	[InstanceEdit:2672293] May, B, 2012-11-27 [InstanceEdit:2672318] May, B, 2012-11-27 [InstanceEdit:3110010] May, B, 2013-02-10 [InstanceEdit:3165219] May, B, 2013-02-22 [InstanceEdit:4420241] May, B, 2013-08-31 [InstanceEdit:4789069] May, B, 2013-10-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated Stat3 Dissociates from Leptin Receptor
output	[Complex:2586540] Lep:p-Lepr:p-Jak2 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:914034] p-Y705-Stat3 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:914034] p-Y705-Stat3 [cytosol] [Mus musculus]
precedingEvent	[Reaction:2671836] Jak2 Phosphorylates Stat3 in Response to Leptin [Mus musculus] [Reaction:2671854] Phosphorylated Lepr Binds Stat3 [Mus musculus]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:4545066] R-MMU-2671877.2
summation	[Summation:2672276] Phosphorylated Stat3 dissociates from Lepr, dimerizes, and t...
(inferredFrom)	[Reaction:2671839] Phosphorylated STAT3 Dissociates from Leptin Receptor [Homo sapiens]
(precedingEvent)	[Reaction:2730597] Phosphorylated Stat3 Forms Dimer [Mus musculus]
(replacementInstances)	[_Deleted:9032439] Deletion of instance: 2586551 [_Deleted:9032440] Deletion of instance: 5334727
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No pathways have been reviewed or authored by Phosphorylated Stat3 Dissociates from Leptin Receptor (2671877)