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Details on Person Phosphorylated Lepr Binds Shp2

Class:Id	Reaction:2671739
_displayName	Phosphorylated Lepr Binds Shp2
_doRelease	TRUE
_timestamp	2013-10-26 10:15:11
authored	[InstanceEdit:2586547] May, B, 2012-11-15
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2671755] May, B, 2012-11-24
edited	[InstanceEdit:2671737] May, B, 2012-11-24
input	[Complex:2586540] Lep:p-Lepr:p-Jak2 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:210002] Ptpn11 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:210002] Ptpn11 [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2671754] Activation of downstream signals by the long form of the leptin receptor [LiteratureReference:2671757] Divergent roles of SHP-2 in ERK activation by leptin receptors [LiteratureReference:2586463] Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
modified	[InstanceEdit:2671764] May, B, 2012-11-24 [InstanceEdit:2671878] May, B, 2012-11-26 [InstanceEdit:2672293] May, B, 2012-11-27 [InstanceEdit:3110010] May, B, 2013-02-10 [InstanceEdit:3165219] May, B, 2013-02-22 [InstanceEdit:4420241] May, B, 2013-08-31 [InstanceEdit:4789069] May, B, 2013-10-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated Lepr Binds Shp2
output	[Complex:2671745] Lep:p-Lepr:p-Jak2:Shp2 [plasma membrane] [Mus musculus]
precedingEvent	[Reaction:2586557] Jak2 Phosphorylates Lepr [Mus musculus] [Reaction:2586548] Jak2 Autophosphorylates in Response to Leptin [Mus musculus]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:4545337] R-MMU-2671739.2
summation	[Summation:2671762] Shp2 interacts with phosphotyrosine-985 of the phosphorylate...
(inferredFrom)	[Reaction:2671747] Phosphorylated LEPR Binds SHP2 (PTPN11) [Homo sapiens]
(precedingEvent)	[Reaction:2671740] Jak2 Phosphorylates Shp2 in Response to Leptin [Mus musculus]
(replacementInstances)	[_Deleted:9032439] Deletion of instance: 2586551 [_Deleted:9032440] Deletion of instance: 5334727
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No pathways have been reviewed or authored by Phosphorylated Lepr Binds Shp2 (2671739)