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Details on Person NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1

Class:Id	Reaction:2666278
_displayName	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
_doRelease	TRUE
_timestamp	2018-02-20 20:10:10
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
catalystActivity	[CatalystActivity:1852619] metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2666276] Orlic-Milacic, M, 2012-11-23
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2666274] gain_of_function of NOTCH1 t(7;9)(NOTCH1:M1580_K2555) [plasma membrane]
input	[Complex:2672451] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:2025693] TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
modified	[InstanceEdit:2672452] Orlic-Milacic, M, 2012-11-27 [InstanceEdit:2981030] Orlic-Milacic, M, 2013-01-14 [InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:9037744] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
output	[EntityWithAccessionedSequence:157200] NEXT1 [plasma membrane] [Homo sapiens] [Complex:2672449] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) fragment [extracellular region] [Homo sapiens]
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200444] R-HSA-2666278.3
summation	[Summation:2666273] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) translocation mutant is su...
(hasEvent)	[Pathway:2660826] Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant [Homo sapiens]
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No pathways have been reviewed or authored by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (2666278)