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Details on Person LTA4 is hydolysed to LTB4 by LTA4H

Class:Id	Reaction:266072
_displayName	LTA4 is hydolysed to LTB4 by LTA4H
_doRelease	TRUE
_timestamp	2024-07-16 22:48:32
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:266024] leukotriene-A4 hydrolase activity of LTA4H:Zn2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:266031] Jassal, B, 2008-04-21 14:30:43
crossReference	[DatabaseIdentifier:9915833] RHEA:22325
edited	[InstanceEdit:266011] Jassal, B, 2008-04-21 14:30:22
input	[SimpleEntity:265281] LTA4 [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:266014] Leukotriene A4 hydrolase in human leukocytes. Purification and properties [LiteratureReference:266036] Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes
modified	[InstanceEdit:372752] Jassal, B, 2008-07-02 12:21:50 [InstanceEdit:378946] Jassal, Bijay, 2008-10-01 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:387041] D'Eustachio, P, 2008-11-29 18:16:22 [InstanceEdit:2162166] Williams, MG, 2012-03-14 [InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915828] D'Eustachio, Peter, 2024-07-16
name	LTA4 is hydolysed to LTB4 by LTA4H H2O + leukotriene A4 => leukotriene B4 LTA4 is hydrolyzed to LTB4
output	[SimpleEntity:266056] LTB4 [cytosol]
precedingEvent	[Reaction:266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 [Homo sapiens] [Reaction:265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387741] R-HSA-266072.3
summation	[Summation:266075] Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enz...
(hasEvent)	[Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Homo sapiens]
(precedingEvent)	[Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 [Homo sapiens] [Reaction:2161567] LTB4 is oxidised to 12-oxoLTB4 by PTGR1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788667] Update Tracker - [Reaction:266072] LTA4 is hydolysed to LTB4 by LTA4H - v41:[modifyText]
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