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Details on Person LTD4 is converted to LTE4 by DPEP1/2

Class:IdReaction:266012
_displayNameLTD4 is converted to LTE4 by DPEP1/2
_doReleaseTRUE
_timestamp2024-07-17 22:41:37
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:266039] dipeptidase activity of DPEP1,2 dimers [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:266031] Jassal, B, 2008-04-21 14:30:43
crossReference[DatabaseIdentifier:9915903] RHEA:48617
edited[InstanceEdit:266011] Jassal, B, 2008-04-21 14:30:22
input[SimpleEntity:266074] LTD4 [extracellular region]
[SimpleEntity:109276] H2O [extracellular region]
literatureReference[LiteratureReference:266028] Release and functional characterization of the leukotriene D4-metabolizing enzyme (dipeptidase) from human polymorphonuclear leucocytes
[LiteratureReference:266042] Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes
[LiteratureReference:2162134] Purification and characterization of human microsomal dipeptidase
modified[InstanceEdit:372752] Jassal, B, 2008-07-02 12:21:50
[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:387041] D'Eustachio, P, 2008-11-29 18:16:22
[InstanceEdit:580230] D'Eustachio, P, 2010-04-10
[InstanceEdit:2162166] Williams, MG, 2012-03-14
[InstanceEdit:2201180] Williams, MG, 2012-04-17
[InstanceEdit:2586592] D'Eustachio, P, 2012-11-15
[InstanceEdit:9664264] Murillo, Julieth, 2019-10-22
[InstanceEdit:9664534] Murillo, Julieth, 2019-10-25
[InstanceEdit:9673429] Murillo, Julieth, 2020-01-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915896] D'Eustachio, Peter, 2024-07-17
nameLTD4 is converted to LTE4 by DPEP1/2
H2O + leukotriene D4 => glycine + leukotriene E4
Further cleavage of LTD4 forms LTE4
output[SimpleEntity:266033] LTE4 [extracellular region]
[SimpleEntity:266029] Gly [extracellular region]
releaseDate2008-12-17
reviewed[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:387658] R-HSA-266012.5
summation[Summation:266054] Another outer surface membrane-bound, homodimeric enzyme, di...
(hasEvent)[Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Homo sapiens]
[Pathway:9664535] LTC4-CYSLTR mediated IL4 production [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788294] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v43:[modifyText]
[_UpdateTracker:9788629] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v41:[addLiteratureReference, modifyText]
[_UpdateTracker:9790621] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v33:[addInput]
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