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Details on Person Association of RAD51 with BRCA1

Class:Id	Reaction:265968
_displayName	Association of RAD51 with BRCA1
_doRelease	TRUE
_timestamp	2011-11-23 11:08:22
authored	[InstanceEdit:209713] Saxena, A, 2008-01-04 18:30:50
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:265962] Saxena, A, 2008-04-21 13:32:36
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
input	[EntityWithAccessionedSequence:216997] RAD51 [nucleoplasm] [Gallus gallus] [EntityWithAccessionedSequence:265944] BRCA1 [nucleoplasm] [Gallus gallus]
literatureReference	[LiteratureReference:75196] Homologous recombinational repair of DNA ensures mammalian chromosome stability [LiteratureReference:265950] A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination [LiteratureReference:266001] RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors [LiteratureReference:265881] Brca1 in immunoglobulin gene conversion and somatic hypermutation
modified	[InstanceEdit:351413] Saxena, A, 2008-05-22 20:44:09 [InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00 [InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07 [InstanceEdit:418966] D'Eustachio, P, 2009-04-27 17:13:45 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of RAD51 with BRCA1
output	[Complex:265909] RAD51-BRCA1 complex [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:265987] Phosphorylation of BRCA1 [Gallus gallus]
regulatedBy	[Requirement:265855] Requirement by 'UBE2N [nucleoplasm]'
regulationReference	[RegulationReference:9641683] Requirement by 'UBE2N [nucleoplasm]' A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
releaseDate	2009-06-01
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016264] R-GGA-265968.4
summation	[Summation:265916] Defects in Brca1 confer susceptibility to breast cancer and ...
(hasEvent)	[Pathway:265976] Homologous DNA pairing and strand exchange [Gallus gallus]
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No pathways have been reviewed or authored by Association of RAD51 with BRCA1 (265968)