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Details on Person Rad51 assembly at the DNA-damage sites on the chromatin

Class:Id	Polymerisation:265940
_displayName	Rad51 assembly at the DNA-damage sites on the chromatin
_doRelease	TRUE
_timestamp	2018-11-09 21:51:55
authored	[InstanceEdit:209713] Saxena, A, 2008-01-04 18:30:50
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:265962] Saxena, A, 2008-04-21 13:32:36
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
input	[EntityWithAccessionedSequence:216957] phospho-RAD51 [nucleoplasm] [Gallus gallus]
literatureReference	[LiteratureReference:265961] Association of BRCA1 with Rad51 in mitotic and meiotic cells [LiteratureReference:265886] BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway [LiteratureReference:265918] CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair [LiteratureReference:265986] In search of the tumour-suppressor functions of BRCA1 and BRCA2 [LiteratureReference:265994] Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes [LiteratureReference:265856] Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 [LiteratureReference:265860] Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
modified	[InstanceEdit:391641] Saxena, A, 2009-02-23 15:55:32 [InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00 [InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07 [InstanceEdit:418966] D'Eustachio, P, 2009-04-27 17:13:45 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9628607] D'Eustachio, Peter, 2018-11-09 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Rad51 assembly at the DNA-damage sites on the chromatin
output	[Polymer:265869] Polymerization of phospho-RAD51as foci [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:217013] Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members [Gallus gallus] [Reaction:217147] Phosphorylation of c-Abl and Arg by ATM [Gallus gallus]
regulatedBy	[PositiveRegulation:265838] Positive regulation by 'BRCA2 [nucleoplasm]' [PositiveRegulation:265935] Positive regulation by 'BRCA1 [nucleoplasm]'
regulationReference	[RegulationReference:9641999] Positive regulation by 'BRCA1 [nucleoplasm]' Brca1 in immunoglobulin gene conversion and somatic hypermutation [RegulationReference:9642524] Positive regulation by 'BRCA2 [nucleoplasm]' Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2
releaseDate	2009-06-01
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016107] R-GGA-265940.5
summation	[Summation:265810] Homologous recombination in vertebrates is catalyzed by Rad5...
(hasEvent)	[Pathway:351433] ATM mediated phosphorylation of repair proteins [Gallus gallus]
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No pathways have been reviewed or authored by Rad51 assembly at the DNA-damage sites on the chromatin (265940)