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Details on Person Defects in Brca1 confer susceptibility to breast cancer and ...
| Class:Id | Summation:265916 |
|---|---|
| _displayName | Defects in Brca1 confer susceptibility to breast cancer and ... |
| _timestamp | 2009-02-23 15:56:30 |
| created | [InstanceEdit:265962] Saxena, A, 2008-04-21 13:32:36 |
| modified | [InstanceEdit:391641] Saxena, A, 2009-02-23 15:55:32 |
| text | Defects in Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 has been implicated in the homologous recombination pathway via effects on the assembly of the Rad51 recombinase. Over-expression of the cognate Rad51 in a DT40 BRCA1Delta/Delta mutant (exon 11 in the BRCA1 gene was disrupted producing a C-terminally truncated protein from both alleles) rescues defects in proliferation, DNA damage survival, and homologous recombination (HR). Although BRCA1 phosphorylation at multiple sites by ATM has been evaluated in humans, it is not yet established with the chicken protein. The ubiquitin (Ub)-conjugating enzyme, Ubc13 is required for the recruitment and activation of the E3 Ub ligase, function of BRCA1 and the subsequent formation of the Rad51 nucleoprotein filament at DSBs. Furthermore, generation of ssDNA/RPA complexes at DSBs is severely attenuated in the absence of vertebrate Ubc13 indicating its critical role in the initiation of HR at the level of DSB processing. |
| (summation) | [Reaction:265968] Association of RAD51 with BRCA1 [Gallus gallus] |
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