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Details on Person KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
Class:Id Reaction:265682 _displayName KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel _doRelease TRUE _timestamp 2018-12-21 09:39:27 authored [InstanceEdit:265162] May, B, 2008-04-15 08:41:29 catalystActivity [CatalystActivity:264517] ATP binding activity of KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] compartment [Compartment:70101] cytosol [Compartment:876] plasma membrane created [InstanceEdit:265678] May, B, 2008-04-20 07:49:26 edited [InstanceEdit:392539] D'Eustachio, P, 2009-03-06 11:49:32 [InstanceEdit:391171] May, B, 2009-02-12 22:40:35 input [Complex:265734] KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] literatureReference [LiteratureReference:445976] A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults [LiteratureReference:445980] Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel [LiteratureReference:445969] Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations [LiteratureReference:445977] A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels [LiteratureReference:445951] Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms [LiteratureReference:445966] Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y [LiteratureReference:445961] Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes [LiteratureReference:445958] The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells [LiteratureReference:445953] Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development [LiteratureReference:264728] Minireview: implication of mitochondria in insulin secretion and action [LiteratureReference:264726] Triggering and amplifying pathways of regulation of insulin secretion by glucose [LiteratureReference:264727] Action potentials and insulin secretion: new insights into the role of Kv channels [LiteratureReference:264719] Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells [LiteratureReference:266004] Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice [LiteratureReference:1296246] Inwardly rectifying potassium channels: their structure, function, and physiological roles modified [InstanceEdit:265760] May, B, 2008-04-20 09:06:58 [InstanceEdit:266005] May, B, 2008-04-21 13:46:27 [InstanceEdit:386980] Gopinathrao, G, 2008-11-29 00:25:46 [InstanceEdit:387046] Gopinathrao, G, 2008-11-29 21:20:30 [InstanceEdit:390382] May, B, 2009-02-02 19:19:16 [InstanceEdit:391484] D'Eustachio, P, 2009-02-22 18:57:28 [InstanceEdit:392538] D'Eustachio, P, 2009-03-06 11:46:44 [InstanceEdit:392821] May, B, 2009-03-09 01:48:21 [InstanceEdit:422156] D'Eustachio, P, 2009-05-26 22:29:40 [InstanceEdit:422317] May, B, 2009-05-28 03:42:07 [InstanceEdit:422556] D'Eustachio, P, 2009-06-02 01:00:41 [InstanceEdit:445970] May, B, 2009-11-07 [InstanceEdit:448968] May, B, 2009-11-27 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5683200] Jassal, Bijay, 2015-03-12 [InstanceEdit:6790055] May, Bruce, 2015-08-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9632754] Jassal, Bijay, 2018-12-21 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel output [Complex:265746] KCNJ11:ATP tetramer:ABCC8 tetramer [plasma membrane] [Homo sapiens] [Complex:6790050] Mg2+:ADP [cytosol] [Complex:6790050] Mg2+:ADP [cytosol] [Complex:6790050] Mg2+:ADP [cytosol] [Complex:6790050] Mg2+:ADP [cytosol] precedingEvent
regulatedBy [PositiveRegulation:422332] Positive regulation by 'PKA catalytic subunit [cytosol]' [PositiveRegulation:446922] Positive regulation by 'RAPGEF4:cAMP Complex [plasma membrane]' [PositiveRegulation:446924] Positive regulation by 'RAPGEF3:cAMP complex [plasma membrane]' [NegativeRegulation:5339572] Negative regulation by 'Zn2+ [extracellular region]' [PositiveRegulation:5683249] Positive regulation by 'Glc [cytosol]' regulationReference [RegulationReference:9641324] Positive regulation by 'RAPGEF3:cAMP complex [plasma membrane]' Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells [RegulationReference:9641757] Positive regulation by 'RAPGEF4:cAMP Complex [plasma membrane]' Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells [RegulationReference:9641802] Positive regulation by 'PKA catalytic subunit [cytosol]' Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism releaseDate 2009-04-01 reviewed [InstanceEdit:422557] Gillespie, ME, 2009-06-02 00:59:01 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:398313] R-HSA-265682.7 summation [Summation:265570] The beta-cell ATP-sensitive potassium channel (KATP channel)... [Summation:446925] Epac2 is activated by binding cAMP, forms a complex with inw... [Summation:381715] Activated PKA promotes the closing of inward rectifying pota... [Summation:446926] Epac1 is activated by binding cAMP, forms a complex with inw... (hasEvent) [Pathway:422356] Regulation of insulin secretion [Homo sapiens] (normalReaction) [FailedReaction:5683113] Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia [Homo sapiens] (precedingEvent) [Reaction:265645] Calcium Influx through Voltage-gated Calcium Channels [Homo sapiens] (updatedInstance) [_UpdateTracker:9775947] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v78:[addSummation] [_UpdateTracker:9784099] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v54:[addLiteratureReference, addOutput, modifyText] [_UpdateTracker:9784638] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v53:[addRegulator, modifyText] [_UpdateTracker:9786576] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v49:[addRegulator] [_UpdateTracker:9791354] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v31:[addRegulator, add_removeLiteratureReference] [_UpdateTracker:9791482] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v29:[addRegulator]
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