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Details on Person Dietary cholesterol is taken up into enterocytes from the gu...
| Class:Id | Summation:265527 |
|---|---|
| _displayName | Dietary cholesterol is taken up into enterocytes from the gu... |
| _timestamp | 2008-04-18 20:08:22 |
| created | [InstanceEdit:265506] D'Eustachio, P, 2008-04-18 20:07:54 |
| literatureReference | [LiteratureReference:265449] Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia [LiteratureReference:265484] Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake [LiteratureReference:265528] Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption |
| text | Dietary cholesterol is taken up into enterocytes from the gut lumen in a reaction mediated by plasma membrane-associated NPC1L1 protein. This role for NPC1L1 was first observed in studies of a mouse model system (Altman et al. 2004). Subsequent studies of human cultured cells confirmed the participation of NPC1L1 in cholesterol transport across membranes but suggested that this transport process might not be a major factor in dietary cholesterol uptake (Davies et al. 2005). Detailed studies in Maden-Darby canine kidney cells, both mediated by endogenous (canine) NPC1L1 and by overexpressed human protein, indicate a major role for NPC1L1 in the uptake of extracellular cholesterol. These studies have also shown that ezetimibe binds both human and canine proteins and renders them incapable of mediating cholesterol uptake. The molecular mechanisms of cholesterol transport and ezetimibe inhibition, however, remain unclear (Weinglass et al. 2008). |
| (summation) | [Reaction:265443] NPC1L1-mediated cholesterol uptake [Homo sapiens] |
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No pathways have been reviewed or authored by Dietary cholesterol is taken up into enterocytes from the gu... (265527)
