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Details on Person NPC1L1 binds ezetimibe

Class:IdReaction:265456
_displayNameNPC1L1 binds ezetimibe
_doReleaseTRUE
_timestamp2021-06-16 14:18:29
authored[InstanceEdit:349660] D'Eustachio, P, 2008-05-12 17:46:52
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:265506] D'Eustachio, P, 2008-04-18 20:07:54
edited[InstanceEdit:353690] D'Eustachio, P, 2008-06-13 14:03:50
input[EntityWithAccessionedSequence:265453] NPC1L1-1 [plasma membrane] [Homo sapiens]
[ChemicalDrug:265479] ezetimibe [extracellular region]
literatureReference[LiteratureReference:265484] Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake
[LiteratureReference:265538] The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
modified[InstanceEdit:349666] D'Eustachio, P, 2008-05-12 17:50:01
[InstanceEdit:350213] D'Eustachio, P, 2008-05-14 17:49:58
[InstanceEdit:353692] D'Eustachio, P, 2008-06-13 14:06:33
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9734253] Jassal, Bijay, 2021-06-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNPC1L1 binds ezetimibe
NPC1L1 inactivation by ezetimibe
NPC1L1 + ezetimibe => NPC1L1:ezetimibe complex
output[Complex:265464] NPC1L1:ezetimibe [plasma membrane] [Homo sapiens]
releaseDate2008-06-30
reviewed[InstanceEdit:353689] Jassal, Bijay, 2008-06-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358491] R-HSA-265456.3
summation[Summation:265485] Human NPC1L1, associated with the plasma membrane, binds eze...
(hasEvent)[Pathway:8963678] Intestinal lipid absorption [Homo sapiens]
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No pathways have been reviewed or authored by NPC1L1 binds ezetimibe (265456)