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Details on Person NPC1L1-mediated cholesterol uptake

Class:Id	Reaction:265443
_displayName	NPC1L1-mediated cholesterol uptake
_doRelease	TRUE
_timestamp	2025-09-13 08:09:36
authored	[InstanceEdit:349660] D'Eustachio, P, 2008-05-12 17:46:52
catalystActivity	[CatalystActivity:352534] cholesterol transfer activity of NPC1L1-1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:265506] D'Eustachio, P, 2008-04-18 20:07:54
crossReference	[DatabaseIdentifier:9966216] RHEA:39749
edited	[InstanceEdit:353690] D'Eustachio, P, 2008-06-13 14:03:50
inferredFrom	[Reaction:265529] NPC1L1-mediated cholesterol uptake [Canis familiaris]
input	[SimpleEntity:171149] CHOL [extracellular region]
modified	[InstanceEdit:349666] D'Eustachio, P, 2008-05-12 17:50:01 [InstanceEdit:350213] D'Eustachio, P, 2008-05-14 17:49:58 [InstanceEdit:352536] D'Eustachio, P, 2008-06-03 19:40:12 [InstanceEdit:353692] D'Eustachio, P, 2008-06-13 14:06:33 [InstanceEdit:9734253] Jassal, Bijay, 2021-06-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9966227] Stephan, Ralf, 2025-09-13
name	NPC1L1-mediated cholesterol uptake
output	[SimpleEntity:176478] CHOL [cytosol]
precedingEvent	[Reaction:192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) [Homo sapiens]
regulatedBy	[NegativeRegulation:9734256] Negative regulation by 'NPC1L1:ezetimibe [plasma membrane]'
regulationReference	[RegulationReference:9734254] Negative regulation by 'NPC1L1:ezetimibe [plasma membrane]' The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
releaseDate	2008-06-30
reviewed	[InstanceEdit:353689] Jassal, Bijay, 2008-06-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358268] R-HSA-265443.4
summation	[Summation:265527] Dietary cholesterol is taken up into enterocytes from the gu...
(hasEvent)	[Pathway:8963678] Intestinal lipid absorption [Homo sapiens]
(inferredFrom)	[Reaction:265545] NPC1L1-mediated phytosterol uptake [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775614] Update Tracker - [Reaction:265443] NPC1L1-mediated cholesterol uptake - v78:[addRegulator] [_UpdateTracker:9790417] Update Tracker - [Reaction:265443] NPC1L1-mediated cholesterol uptake - v33:[removeRegulator]
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No pathways have been reviewed or authored by NPC1L1-mediated cholesterol uptake (265443)