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Details on Person Arachidonate is oxidised to 5S-HpETE by ALOX5

Class:Id	Reaction:265296
_displayName	Arachidonate is oxidised to 5S-HpETE by ALOX5
_doRelease	TRUE
_timestamp	2024-07-31 13:54:22
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:265275] oxidoreductase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:265270] Jassal, B, 2008-04-17 12:12:14
crossReference	[DatabaseIdentifier:9915839] RHEA:17486
edited	[InstanceEdit:266011] Jassal, B, 2008-04-21 14:30:22
input	[SimpleEntity:29768] AA [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:265274] Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase [LiteratureReference:265292] Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells [LiteratureReference:265278] Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities
modified	[InstanceEdit:265299] Jassal, B, 2008-04-17 12:29:21 [InstanceEdit:265307] Jassal, B, 2008-04-17 14:18:54 [InstanceEdit:265310] Jassal, B, 2008-04-17 14:40:08 [InstanceEdit:266011] Jassal, B, 2008-04-21 14:30:22 [InstanceEdit:372752] Jassal, B, 2008-07-02 12:21:50 [InstanceEdit:378946] Jassal, Bijay, 2008-10-01 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:387041] D'Eustachio, P, 2008-11-29 18:16:22 [InstanceEdit:429021] Jupe, S, 2009-07-14 [InstanceEdit:2162165] Williams, MG, 2012-03-14 [InstanceEdit:2308243] D'Eustachio, P, 2012-06-04 [InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915828] D'Eustachio, Peter, 2024-07-16 [InstanceEdit:9917185] D'Eustachio, Peter, 2024-07-31
name	Arachidonate is oxidised to 5S-HpETE by ALOX5 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate Oxidation of arachidonic acid to 5-HpETE
output	[SimpleEntity:266010] 5S-HpETE [cytosol]
precedingEvent	[Reaction:429016] ALOX5 is phosphorylated by MAPKAP2 [Homo sapiens] [Reaction:428990] SLC27A1 transports arachidonate across the ER membrane [Homo sapiens] [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387600] R-HSA-265296.3
summation	[Summation:265288] Arachidonate 5-lipoxygenase (ALOX5) catalyzes the formation ...
(hasEvent)	[Pathway:2142688] Synthesis of 5-eicosatetraenoic acids [Homo sapiens] [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Homo sapiens]
(precedingEvent)	[Reaction:266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 [Homo sapiens] [Reaction:2161946] 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788638] Update Tracker - [Reaction:265296] Arachidonic acid is oxidised to 5S-HpETE by ALOX5 - v41:[modifyText] [_UpdateTracker:9919394] Update Tracker - [Reaction:265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - v90:[modifyText]
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