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Details on Person Exocytosis of Insulin

Class:Id	BlackBoxEvent:265166
_displayName	Exocytosis of Insulin
_doRelease	TRUE
_timestamp	2025-04-30 21:58:29
authored	[InstanceEdit:349842] May, B, 2008-05-13 13:18:27
catalystActivity	[CatalystActivity:387385] SNARE binding activity of Core SNARE Complex [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:216813] secretory granule membrane
created	[InstanceEdit:265162] May, B, 2008-04-15 08:41:29
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
figure	[Figure:266136] /figures/InsulinExocytosis1.jpg [Figure:266137] /figures/InsulinExocytosis2.jpg
goBiologicalProcess	[GO_BiologicalProcess:19568] insulin secretion
inferredFrom	[BlackBoxEvent:216883] Exocytosis of Insulin [Mus musculus]
input	[EntityWithAccessionedSequence:2029017] SNAP25 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:265193] SYT5 [secretory granule membrane] [Homo sapiens] [SimpleEntity:74016] Ca2+ [cytosol] [Complex:265191] STX1A:STXBP1 [plasma membrane] [Homo sapiens] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [Complex:386977] 6xInsulin:2xZn2+:Ca2+ (docked granule) [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:265011] C Peptide [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:376363] VAMP2 [secretory granule membrane] [Homo sapiens]
literatureReference	[LiteratureReference:445603] Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients [LiteratureReference:445607] Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus [LiteratureReference:264310] Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells [LiteratureReference:264300] Insulin secretion: a high-affinity Ca2+ sensor after all? [LiteratureReference:264260] Insulin vesicle release: walk, kiss, pause ... then run [LiteratureReference:264297] Molecular determinants of regulated exocytosis [LiteratureReference:264263] Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion [LiteratureReference:264262] Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion [LiteratureReference:400089] Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits [LiteratureReference:400064] Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2 [LiteratureReference:400054] Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400059] Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice [LiteratureReference:400072] Mechanisms of inhibition of insulin release [LiteratureReference:446521] Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase
modified	[InstanceEdit:265266] May, B, 2008-04-17 07:32:17 [InstanceEdit:265268] May, B, 2008-04-17 08:36:08 [InstanceEdit:265770] May, B, 2008-04-20 10:25:09 [InstanceEdit:266139] May, B, 2008-04-25 04:01:01 [InstanceEdit:349827] May, B, 2008-05-13 12:28:12 [InstanceEdit:349842] May, B, 2008-05-13 13:18:27 [InstanceEdit:381397] May, B, 2008-11-19 19:24:45 [InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07 [InstanceEdit:386974] Gopinathrao, G, 2008-11-29 00:14:24 [InstanceEdit:386978] Gopinathrao, G, 2008-11-29 00:22:38 [InstanceEdit:387386] Gillespie, ME, 2008-12-02 04:21:36 [InstanceEdit:387409] May, B, 2008-12-02 09:56:48 [InstanceEdit:387414] May, B, 2008-12-02 15:36:10 [InstanceEdit:387469] Gopinathrao, G, 2008-12-02 17:52:42 [InstanceEdit:391171] May, B, 2009-02-12 22:40:35 [InstanceEdit:399971] May, B, 2009-03-24 01:45:24 [InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55 [InstanceEdit:422553] D'Eustachio, P, 2009-06-02 00:57:15 [InstanceEdit:426571] May, B, 2009-06-16 [InstanceEdit:445606] May, B, 2009-10-31 [InstanceEdit:660804] D'Eustachio, P, 2010-05-01 [InstanceEdit:2980864] Jassal, B, 2013-01-14 [InstanceEdit:3004547] Jassal, Bijay, 2013-01-29 [InstanceEdit:5339583] Jassal, Bijay, 2014-03-06 [InstanceEdit:5339596] Jassal, Bijay, 2014-03-06 [InstanceEdit:5339617] Jassal, B, 2014-03-07 [InstanceEdit:9023238] May, Bruce, 2017-09-27 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9763798] D'Eustachio, Peter, 2022-02-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857755] D'Eustachio, Peter, 2024-01-08 [InstanceEdit:9947017] D'Eustachio, Peter, 2025-04-30
name	Exocytosis of Insulin
output	[Complex:265202] SNARE Complex [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2980862] STXBP1 [plasma membrane] [Homo sapiens] [SimpleEntity:158417] Zn2+ [extracellular region] [SimpleEntity:158417] Zn2+ [extracellular region] [Complex:74674] Insulin [extracellular region] [Homo sapiens] [Complex:74674] Insulin [extracellular region] [Homo sapiens] [Complex:74674] Insulin [extracellular region] [Homo sapiens] [Complex:74674] Insulin [extracellular region] [Homo sapiens] [Complex:74674] Insulin [extracellular region] [Homo sapiens] [Complex:74674] Insulin [extracellular region] [Homo sapiens] [SimpleEntity:74112] Ca2+ [extracellular region] [EntityWithAccessionedSequence:265157] INS(57-87) [extracellular region] [Homo sapiens] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region]
precedingEvent	[Reaction:265645] Calcium Influx through Voltage-gated Calcium Channels [Homo sapiens] [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel [Homo sapiens] [BlackBoxEvent:381713] Potassium voltage-gated channels close in reponse to PKA [Homo sapiens] [BlackBoxEvent:381644] ER calcium channels open in response to activated PKA [Homo sapiens] [Reaction:381707] PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP [Homo sapiens] [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol [Homo sapiens] [Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel [Homo sapiens] [Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens]
regulatedBy	[NegativeRegulation:422251] Negative regulation by 'G-alpha(i,o):GTP [plasma membrane]' [NegativeRegulation:741369] Negative regulation by 'Voltage-gated Calcium Channels Type Cav1 (closed) [plasma membrane]' [NegativeRegulation:741372] Negative regulation by 'Potassium Channel, open (pancreatic beta cell) [plasma membrane]'
regulationReference	[RegulationReference:9642641] Negative regulation by 'Voltage-gated Calcium Channels Type Cav1 (closed) [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [RegulationReference:9642657] Negative regulation by 'G-alpha(i,o):GTP [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [RegulationReference:9643006] Negative regulation by 'Potassium Channel, open (pancreatic beta cell) [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel
releaseDate	2008-12-17
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387589] R-HSA-265166.9
summation	[Summation:265194] Exocytosis of insulin-zinc granules occurs by the calcium-de...
(hasEvent)	[Pathway:422356] Regulation of insulin secretion [Homo sapiens]
(replacementInstances)	[_Deleted:660805] Deletion of instance: 400073
(updatedInstance)	[_UpdateTracker:9775035] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v80:[add_removeInput] [_UpdateTracker:9776083] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v78:[addSummation] [_UpdateTracker:9786560] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v49:[add_removeOutput, modifyText, removeRegulator] [_UpdateTracker:9787945] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v44:[add_removeInput, add_removeOutput] [_UpdateTracker:9790358] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v33:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9791307] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v31:[add_removeLiteratureReference] [_UpdateTracker:9791475] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v30:[addRegulator] [_UpdateTracker:9791543] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v29:[addRegulator] [_UpdateTracker:9791599] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v28:[modifyText] [_UpdateTracker:9864194] Update Tracker - [BlackBoxEvent:265166] Exocytosis of Insulin - v88:[modifyText, removeSummation]
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