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Details on Person Proinsulin:Zinc:Calcium complex translocates to immature secretory granule

Class:Id	BlackBoxEvent:265153
_displayName	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule
_doRelease	TRUE
_timestamp	2022-09-26 16:35:40
authored	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
compartment	[Compartment:13951] Golgi-associated vesicle
created	[InstanceEdit:265162] May, B, 2008-04-15 08:41:29
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
input	[Complex:264908] 6xProinsulin:2xZn2+:1xCa2+ [Golgi lumen] [Homo sapiens]
literatureReference	[LiteratureReference:264281] The role of assembly in insulin's biosynthesis [LiteratureReference:445479] Direct identification of prohormone conversion site in insulin-secreting cells
modified	[InstanceEdit:265266] May, B, 2008-04-17 07:32:17 [InstanceEdit:265267] May, B, 2008-04-17 07:51:25 [InstanceEdit:381397] May, B, 2008-11-19 19:24:45 [InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07 [InstanceEdit:386974] Gopinathrao, G, 2008-11-29 00:14:24 [InstanceEdit:387425] May, B, 2008-12-02 15:41:24 [InstanceEdit:387469] Gopinathrao, G, 2008-12-02 17:52:42 [InstanceEdit:445287] May, B, 2009-10-29 [InstanceEdit:445556] May, B, 2009-10-31 [InstanceEdit:453159] May, B, 2010-01-18 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:9817768] D'Eustachio, Peter, 2022-09-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule
output	[Complex:265073] 6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen] [Homo sapiens]
precedingEvent	[Reaction:264976] Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium [Homo sapiens] [BlackBoxEvent:265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi [Homo sapiens] [Reaction:437139] ZnT8 transports zinc into the Golgi apparatus [Homo sapiens] [Reaction:9820566] ZnT5 transports zinc into the golgi apparatus [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387626] R-HSA-265153.3
summation	[Summation:265207] Immature, clathrin-coated vesicles containing proinsulin-zin...
(hasEvent)	[Pathway:264876] Insulin processing [Homo sapiens]
(precedingEvent)	[Reaction:9023196] PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790854] Update Tracker - [BlackBoxEvent:265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule - v32:[removeCatalystActivity] [_UpdateTracker:9791366] Update Tracker - [BlackBoxEvent:265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule - v31:[addLiteratureReference] [_UpdateTracker:9846873] Update Tracker - [BlackBoxEvent:265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule - v83:[modifyText]
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