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Details on Person Proinsulin translocates from the endoplasmic reticulum to the Golgi

Class:Id	BlackBoxEvent:265010
_displayName	Proinsulin translocates from the endoplasmic reticulum to the Golgi
_doRelease	TRUE
_timestamp	2022-09-23 20:33:49
authored	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
compartment	[Compartment:13959] COPII-coated ER to Golgi transport vesicle
created	[InstanceEdit:265053] May, B, 2008-04-15 03:12:38
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
input	[EntityWithAccessionedSequence:265075] 6xHC-INS(25-110) [endoplasmic reticulum lumen] [Homo sapiens]
literatureReference	[LiteratureReference:445479] Direct identification of prohormone conversion site in insulin-secreting cells [LiteratureReference:264281] The role of assembly in insulin's biosynthesis
modified	[InstanceEdit:265266] May, B, 2008-04-17 07:32:17 [InstanceEdit:265267] May, B, 2008-04-17 07:51:25 [InstanceEdit:381397] May, B, 2008-11-19 19:24:45 [InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07 [InstanceEdit:386974] Gopinathrao, G, 2008-11-29 00:14:24 [InstanceEdit:387410] May, B, 2008-12-02 09:57:27 [InstanceEdit:387422] May, B, 2008-12-02 15:40:09 [InstanceEdit:387469] Gopinathrao, G, 2008-12-02 17:52:42 [InstanceEdit:445262] May, B, 2009-10-29 [InstanceEdit:445544] May, B, 2009-10-31 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:9817556] D'Eustachio, Peter, 2022-09-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proinsulin translocates from the endoplasmic reticulum to the Golgi
output	[EntityWithAccessionedSequence:264890] 6xHC-INS(25-110) [Golgi lumen] [Homo sapiens]
precedingEvent	[Reaction:264997] P4HB mediates disulfide bond formation in Proinsulin [Homo sapiens] [BlackBoxEvent:211289] MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein [Homo sapiens] [Reaction:1799329] Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387773] R-HSA-265010.3
summation	[Summation:264983] Correctly folded, disulfide-bonded proinsulin in the endopla...
(hasEvent)	[Pathway:264876] Insulin processing [Homo sapiens]
(precedingEvent)	[Reaction:264976] Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791312] Update Tracker - [BlackBoxEvent:265010] Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi - v31:[addLiteratureReference] [_UpdateTracker:9846931] Update Tracker - [BlackBoxEvent:265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi - v83:[modifyText]
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