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Details on Person Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium

Class:Id	Reaction:264976
_displayName	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium
_doRelease	TRUE
_timestamp	2022-11-09 23:07:56
authored	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:265053] May, B, 2008-04-15 03:12:38
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
figure	[Figure:387434] /figures/Dunn2005-ProinsulinZnCaComplex.jpg
input	[SimpleEntity:216667] Zn2+ [Golgi lumen] [EntityWithAccessionedSequence:264890] 6xHC-INS(25-110) [Golgi lumen] [Homo sapiens] [SimpleEntity:167012] Ca2+ [Golgi lumen] [SimpleEntity:216667] Zn2+ [Golgi lumen] [EntityWithAccessionedSequence:264890] 6xHC-INS(25-110) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:264890] 6xHC-INS(25-110) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:264890] 6xHC-INS(25-110) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:264890] 6xHC-INS(25-110) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:264890] 6xHC-INS(25-110) [Golgi lumen] [Homo sapiens]
literatureReference	[LiteratureReference:445461] Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin [LiteratureReference:445463] Role of metal ions in the T- to R-allosteric transition in the insulin hexamer [LiteratureReference:264279] Overview of mammalian zinc transporters [LiteratureReference:264281] The role of assembly in insulin's biosynthesis [LiteratureReference:264278] Zinc-ligand interactions modulate assembly and stability of the insulin hexamer -- a review
modified	[InstanceEdit:265266] May, B, 2008-04-17 07:32:17 [InstanceEdit:265267] May, B, 2008-04-17 07:51:25 [InstanceEdit:381397] May, B, 2008-11-19 19:24:45 [InstanceEdit:383210] Gopinathrao, G, 2008-11-24 14:43:07 [InstanceEdit:386974] Gopinathrao, G, 2008-11-29 00:14:24 [InstanceEdit:387415] May, B, 2008-12-02 15:36:46 [InstanceEdit:387440] May, B, 2008-12-02 17:07:26 [InstanceEdit:387469] Gopinathrao, G, 2008-12-02 17:52:42 [InstanceEdit:445167] May, B, 2009-10-29 [InstanceEdit:445458] May, B, 2009-10-31 [InstanceEdit:453158] May, B, 2010-01-18 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:5339618] Jassal, B, 2014-03-07 [InstanceEdit:5339746] May, B, 2014-03-08 [InstanceEdit:5340101] May, B, 2014-03-08 [InstanceEdit:5545497] May, Bruce, 2014-05-22 [InstanceEdit:9820568] D'Eustachio, Peter, 2022-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium
output	[Complex:264908] 6xProinsulin:2xZn2+:1xCa2+ [Golgi lumen] [Homo sapiens]
precedingEvent	[BlackBoxEvent:265010] Proinsulin translocates from the endoplasmic reticulum to the Golgi [Homo sapiens] [Reaction:264997] P4HB mediates disulfide bond formation in Proinsulin [Homo sapiens] [Reaction:437139] ZnT8 transports zinc into the Golgi apparatus [Homo sapiens] [Reaction:442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol [Homo sapiens] [Reaction:442317] ZIP6 and ZIP14 mediate zinc influx into cells [Homo sapiens] [Reaction:442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum [Homo sapiens] [Reaction:442387] ZIP8 mediates zinc influx into cells [Homo sapiens] [Reaction:442345] hZIP10 mediates zinc influx into cells [Homo sapiens] [Reaction:442405] hZIP5 mediates zinc uptake by cells [Homo sapiens] [Reaction:9820566] ZnT5 transports zinc into the golgi apparatus [Homo sapiens] [Reaction:442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol [Homo sapiens] [Reaction:442317] ZIP6 and ZIP14 mediate zinc influx into cells [Homo sapiens] [Reaction:442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum [Homo sapiens] [Reaction:442387] ZIP8 mediates zinc influx into cells [Homo sapiens] [Reaction:442345] hZIP10 mediates zinc influx into cells [Homo sapiens] [Reaction:442405] hZIP5 mediates zinc uptake by cells [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387760] R-HSA-264976.3
summation	[Summation:265059] In the presence of high concentrations of zinc and calcium, ...
(hasEvent)	[Pathway:264876] Insulin processing [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:265153] Proinsulin:Zinc:Calcium complex translocates to immature secretory granule [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786585] Update Tracker - [Reaction:264976] Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium - v49:[removeCatalystActivity] [_UpdateTracker:9791015] Update Tracker - [Reaction:264976] Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium - v32:[add_removeCatalystActivity] [_UpdateTracker:9791270] Update Tracker - [Reaction:264976] Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium - v31:[addLiteratureReference]
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No pathways have been reviewed or authored by Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (264976)