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Details on Person Signal Recognition Particle [cytosol]

Class:Id	Complex:264932
_displayName	Signal Recognition Particle [cytosol]
_timestamp	2011-10-23 16:19:07
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:265053] May, B, 2008-04-15 03:12:38
goCellularComponent	[GO_CellularComponent:17955] signal recognition particle, endoplasmic reticulum targeting
hasComponent	[EntityWithAccessionedSequence:264941] SRP14 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:264956] SRP19 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:264977] SRP54 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:265069] SRP72 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:265038] SRP9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:445234] SRP68 [cytosol] [Homo sapiens] [DefinedSet:445238] 7SL RNA [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:445236] Induced structural changes of 7SL RNA during the assembly of human signal recognition particle [LiteratureReference:445240] Protein-induced conformational changes of RNA during the assembly of human signal recognition particle [LiteratureReference:445242] Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis [LiteratureReference:445257] Identification of the RNA binding regions of SRP68/72 and SRP72 by systematic mutagenesis of human SRP RNA [LiteratureReference:445255] Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control [LiteratureReference:445248] Visualizing induced fit in early assembly of the human signal recognition particle [LiteratureReference:445245] Expression, purification, and crystallography of the conserved methionine-rich domain of human signal recognition particle 54 kDa protein [LiteratureReference:445235] Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9 [LiteratureReference:445231] Recognition of a tetranucleotide loop of signal recognition particle RNA by protein SRP19 [LiteratureReference:445233] Targeting proteins to membranes: structure of the signal recognition particle
modified	[InstanceEdit:349822] May, B, 2008-05-13 12:20:58 [InstanceEdit:445246] May, B, 2009-10-29 [InstanceEdit:1799328] D'Eustachio, P, 2011-10-23 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name	Signal Recognition Particle signal recognition particle, endoplasmic reticulum targeting
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387926] R-HSA-264932.19
(hasComponent)	[Complex:265033] Preproinsulin-SRP Complex [cytosol] [Homo sapiens] [Complex:445290] Preprolactin-SRP Complex [cytosol] [Homo sapiens] [Complex:1799337] SRP:polypeptide+signal:ribosome [cytosol] [Homo sapiens] [Complex:9988082] SRP receptor:SRP:nascent ER-targeted polypeptide with signal peptide:80S ribosome:mRNA [endoplasmic reticulum membrane] [Homo sapiens] [Complex:9988190] SRP:GDP [cytosol] [Homo sapiens] [Complex:9988193] SRP:GTP [cytosol] [Homo sapiens]
(input)	[Reaction:445292] Signal Recognition (Preprolactin) [Homo sapiens] [Reaction:1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) [Homo sapiens] [Reaction:9988100] Nascent ER-targeted polypeptide:80S ribosome:mRNA binds signal recognition particle (SRP):GTP [Homo sapiens]
(output)	[Reaction:934660] Translocation of Preprolactin to the Endoplasmic Reticulum [Homo sapiens] [Reaction:1799326] Signal-containing nascent peptide translocates to endoplasmic reticulum [Homo sapiens] [Reaction:9986704] SRP:SRP receptor transfers nascent membrane polypeptide to SEC61 translocon:TRAP complex [Homo sapiens]
(physicalEntity)	[CatalystActivity:265086] signal sequence binding activity of Signal Recognition Particle [cytosol]
(updatedInstance)	[_UpdateTracker:9868508] Update Tracker - [Complex:264932] Signal Recognition Particle [cytosol] - v31:[addLiteratureReference, add_removeHasComponent] [_UpdateTracker:9870958] Update Tracker - [Complex:264932] Signal Recognition Particle [cytosol] - v39:[modifyName]
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No pathways have been reviewed or authored by Signal Recognition Particle [cytosol] (264932)