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Details on Person Caspase-mediated cleavage of Lamin A

Class:Id	Reaction:264865
_displayName	Caspase-mediated cleavage of Lamin A
_doRelease	TRUE
_timestamp	2017-11-21 19:31:38
authored	[InstanceEdit:352235] Schulze-Osthoff, K, 2008-05-18 10:00:05
catalystActivity	[CatalystActivity:352254] cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:264863] Matthews, L, 2008-04-13 23:12:20
edited	[InstanceEdit:264864] Matthews, L, 2008-04-13 23:06:00 [InstanceEdit:352239] Matthews, L, 2008-06-02 07:41:19
input	[EntityWithAccessionedSequence:264866] Lamin A [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:352250] Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells [LiteratureReference:352258] The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A
modified	[InstanceEdit:351919] Matthews, L, 2008-05-28 22:38:42 [InstanceEdit:352259] Matthews, L, 2008-06-02 07:49:06 [InstanceEdit:352465] Matthews, L, 2008-06-03 00:23:29 [InstanceEdit:353176] Matthews, L, 2008-06-12 00:23:53 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9029696] Orlic-Milacic, Marija, 2017-11-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-mediated cleavage of Lamin A
output	[EntityWithAccessionedSequence:352249] LMNA(231-664) [nuclear envelope] [Homo sapiens] [EntityWithAccessionedSequence:352253] LMNA(1-230) [nuclear envelope] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9029690] Caspase-6 translocates to the nucleus [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358910] R-HSA-264865.3
summation	[Summation:352241] Caspases initiate the destruction of the nucleus cleavage of...
(hasEvent)	[Pathway:352238] Breakdown of the nuclear lamina [Homo sapiens]
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No pathways have been reviewed or authored by Caspase-mediated cleavage of Lamin A (264865)