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Details on Person BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1

Class:Id	Reaction:264758
_displayName	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1
_doRelease	TRUE
_timestamp	2015-03-05 15:21:12
authored	[InstanceEdit:349660] D'Eustachio, P, 2008-05-12 17:46:52
catalystActivity	[CatalystActivity:264761] metalloendopeptidase activity of BMP1-3:Zn2+ [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:264766] D'Eustachio, P, 2008-04-06 23:06:04
edited	[InstanceEdit:353690] D'Eustachio, P, 2008-06-13 14:03:50
input	[EntityWithAccessionedSequence:264771] APOA1(19-267) [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:264763] Bone morphogenetic protein-1 (BMP-1) cleaves human proapolipoprotein A1 and regulates its activation for lipid binding [LiteratureReference:264767] Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin [LiteratureReference:264765] Mechanism of prebeta-HDL formation and activation
modified	[InstanceEdit:264773] D'Eustachio, P, 2008-04-06 23:07:08 [InstanceEdit:266295] D'Eustachio, P, 2008-05-02 20:13:11 [InstanceEdit:266359] Gopinathrao, G, 2008-05-06 14:37:06 [InstanceEdit:349666] D'Eustachio, P, 2008-05-12 17:50:01 [InstanceEdit:353692] D'Eustachio, P, 2008-06-13 14:06:33 [InstanceEdit:5682078] Jassal, Bijay, 2015-03-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1
output	[EntityWithAccessionedSequence:174720] APOA1(25-267) [extracellular region] [Homo sapiens]
regulatedBy	[NegativeRegulation:264772] Negative regulation by 'A2M tetramer [extracellular region]'
releaseDate	2008-06-30
reviewed	[InstanceEdit:353689] Jassal, Bijay, 2008-06-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358237] R-HSA-264758.3
summation	[Summation:264764] The six aminoterminal residues of pro-apolipoprotein A-1 are...
(hasEvent)	[Pathway:8963896] HDL assembly [Homo sapiens]
(precedingEvent)	[Reaction:216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784705] Update Tracker - [Reaction:264758] BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 - v53:[modifyText]
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No pathways have been reviewed or authored by BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (264758)