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Details on Person Loading of acetylcholine in synaptic vesicles

Class:Id	Reaction:264615
_displayName	Loading of acetylcholine in synaptic vesicles
_doRelease	TRUE
_timestamp	2020-01-24 22:39:42
authored	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity	[CatalystActivity:264621] acetylcholine transmembrane transporter activity of SLC18A3 [clathrin-sculpted acetylcholine transport vesicle membrane]
compartment	[Compartment:70101] cytosol [Compartment:372525] clathrin-sculpted acetylcholine transport vesicle lumen
input	[SimpleEntity:264643] AcCho [cytosol] [Complex:210372] Empty Acetylcholine Synaptic Vesicle [cytosol] [Homo sapiens] [SimpleEntity:372511] H+ [clathrin-sculpted acetylcholine transport vesicle lumen] [SimpleEntity:372511] H+ [clathrin-sculpted acetylcholine transport vesicle lumen]
literatureReference	[LiteratureReference:373213] Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus
modified	[InstanceEdit:264644] Saxena, A, 2008-04-04 19:41:51 [InstanceEdit:264789] Gillespie, ME, 2008-04-07 13:55:58 [InstanceEdit:264794] Gillespie, ME, 2008-04-07 13:57:37 [InstanceEdit:264814] Mahajan, SS, 2008-04-07 14:52:12 [InstanceEdit:350548] Mahajan, SS, 2008-05-19 15:52:58 [InstanceEdit:372555] Mahajan, SS, 2008-06-26 19:01:12 [InstanceEdit:374942] Mahajan, SS, 2008-08-05 20:37:09 [InstanceEdit:383392] Gillespie, ME, 2008-11-26 16:16:16 [InstanceEdit:387216] Gopinathrao, G, 2008-12-01 18:17:33 [InstanceEdit:2648976] D'Eustachio, P, 2012-11-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9674803] Gillespie, Marc E, 2020-01-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Loading of acetylcholine in synaptic vesicles
output	[Complex:264786] Acetylcholine Loaded Synaptic Vesicle [cytosol] [Homo sapiens] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:264622] Cho is acetylated to AcCho by CHAT [Homo sapiens] [Reaction:429594] SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol [Homo sapiens] [Reaction:1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Homo sapiens] [Reaction:1483159] PCho is dephosphorylated to Cho by PHOSPHO1 [Homo sapiens] [Reaction:444433] Cho transports from the extracellular space to the cytosol [Homo sapiens] [Reaction:1483116] GPCho is hydrolyzed to Cho and G3P by GPCPD1 [Homo sapiens] [BlackBoxEvent:349520] Re-acidification of acetylcholine transport vesicles [Homo sapiens]
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387580] R-HSA-264615.4
summation	[Summation:373199] Acetylcholine is actively transported from the cytosol to th...
(hasEvent)	[Pathway:264642] Acetylcholine Neurotransmitter Release Cycle [Homo sapiens]
(precedingEvent)	[Reaction:372505] Acetylcholine synaptic vesicle docking and priming [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777403] Update Tracker - [Reaction:264615] Loading of acetylcholine in synaptic vesicles - v72:[modifyText]
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