Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Voltage-gated calcium channels respond to a change in voltag...
| Class:Id | Summation:264550 |
|---|---|
| _displayName | Voltage-gated calcium channels respond to a change in voltag... |
| _timestamp | 2008-04-06 04:50:20 |
| created | [InstanceEdit:264554] May, B, 2008-04-03 13:46:49 |
| modified | [InstanceEdit:264602] May, B, 2008-04-04 13:33:02 [InstanceEdit:264756] May, B, 2008-04-06 04:50:08 |
| text | Voltage-gated calcium channels respond to a change in voltage across the plasma membrane by opening and allowing free movement of calcium ions. In an unstimulated cell the concentration of calcium ions outside the cells is higher than inside due to ??? calcium transporters. When voltage gated calcium channels open in response to the change in voltage caused by potassium channel closing, the result is an influx of calcium into the cytosol. In the cytosol the calcium ions cause an immediate exocytosis of the readily releasable pool of docked insulin granules as well as a migration of reserve granules toward the plasma membrane where they will be released during the second, sustained phase of insulin secretion. Mouse beta cells are known to contain L-type channels Cav1.2 and Cav1.3, both of which have been shown to physically associate with docked insulin granules via Syntaxin1A. Cav1.2 and Cav1.3 predominate in the initial rapid release of insulin. Beta cells also contain the P/Q-type channel Cav2.1 and the R-type channel Cav2.3. Cav2.3 is involved in regulating the second, sustained phase of insulin release, however signaling and regulatory differences between the two phases of secretion are not fully characterized. |
| (summation) | [Reaction:264563] Calcium Influx through Voltage-gated Calcium Channels [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Voltage-gated calcium channels respond to a change in voltag... (264550)
