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Details on Person Autoubiquitination of phospho-COP1(Ser-387 )

Class:Id	Reaction:264444
_displayName	Autoubiquitination of phospho-COP1(Ser-387 )
_doRelease	TRUE
_timestamp	2022-02-22 12:56:30
authored	[InstanceEdit:353601] Matthews, L, 2008-06-12 21:09:06
catalystActivity	[CatalystActivity:349467] ubiquitin-protein transferase activity of p-S387-RFWD2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:264445] Matthews, L, 2008-03-31 11:53:02
edited	[InstanceEdit:349470] Matthews, L, 2008-04-30 12:41:30
input	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:349439] p-S387-RFWD2 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:349437] ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
modified	[InstanceEdit:349466] Matthews, L, 2008-05-07 22:49:21 [InstanceEdit:352043] Matthews, L, 2008-05-29 21:34:10 [InstanceEdit:352044] Matthews, L, 2008-05-29 21:40:29 [InstanceEdit:352490] Matthews, L, 2008-06-03 01:07:17 [InstanceEdit:354036] Matthews, L, 2008-06-14 07:26:39 [InstanceEdit:446709] Matthews, L, 2009-11-17 [InstanceEdit:446713] Matthews, L, 2009-11-17 [InstanceEdit:451788] Matthews, L, 2010-01-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9749039] Matthews, Lisa, 2021-07-29 [InstanceEdit:9766481] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autoubiquitination of phospho-COP1(Ser-387 )
negativePrecedingEvent	[NegativePrecedingEvent:9749040] Abundant Molecules: Proteasome mediated degradation of COP1 [NegativePrecedingEvent:9749038] Abundant Molecules: Proteolytic degradation of ubiquitinated-Cdc25A [NegativePrecedingEvent:9766475] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53
output	[Complex:349433] ubiquitinated phospho-COP1(ser-387) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:264418] Translocation of COP1 from the nucleus to the cytoplasm [Homo sapiens] [Reaction:349444] Phosphorylation of COP1 at Ser-387 by ATM [Homo sapiens] [Reaction:264435] Dissociation of the COP1-p53 complex [Homo sapiens]
releaseDate	2009-12-15
reviewed	[InstanceEdit:446711] Dixit, VM, 2009-11-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105534] R-HSA-264444.5
summation	[Summation:349434] ATM phosphorylation promotes autoubiquitination of COP1 in v...
(hasEvent)	[Pathway:349425] Autodegradation of the E3 ubiquitin ligase COP1 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:264458] Proteasome mediated degradation of COP1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791035] Update Tracker - [Reaction:264444] Autoubiquitination of phospho-COP1(Ser-387 ) - v32:[add_removeInput]
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