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Details on Person mediator complex

Class:Id	GO_CellularComponent:25936
_displayName	mediator complex
_timestamp	2009-11-21 18:37:34
accession	0016592
componentOf	[Compartment:7660] nucleoplasm [GO_CellularComponent:171405] nuclear lumen [GO_CellularComponent:352] nucleus
definition	A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
hasPart	[GO_CellularComponent:436635] core mediator complex
instanceOf	[GO_CellularComponent:9715812] nuclear protein-containing complex [GO_CellularComponent:258170] protein-containing complex [GO_CellularComponent:357] cellular_component
modified	[InstanceEdit:160533] Schmidt, EE, 2005-03-23 05:24:35 [InstanceEdit:162607] Schmidt, EE, 2005-04-01 11:06:09 [InstanceEdit:171322] Schmidt, EE, 2006-02-06 10:50:16 [InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20 [InstanceEdit:357819] Kanapin, EE, 2008-06-18 10:45:39 [InstanceEdit:376438] Kanapin, EE, 2008-09-08 10:23:04 [InstanceEdit:383393] Kanapin, AA, 2008-11-26 13:49:44 [InstanceEdit:396309] Kanapin, EE, 2009-03-09 13:26:57 [InstanceEdit:422569] Kanapin, EE [InstanceEdit:436347] Kanapin, EE [InstanceEdit:447572] Kanapin, EE [InstanceEdit:526073] Kanapin, AA [InstanceEdit:528085] Kanapin, AA [InstanceEdit:615500] Kanapin, AA [InstanceEdit:797782] Kanapin, AA [InstanceEdit:937668] Yung, CK [InstanceEdit:1042299] Yung, CK [InstanceEdit:1220942] Yung, CK [InstanceEdit:1301023] Yung, CK [InstanceEdit:1552540] Yung, CK [InstanceEdit:1996004] Yung, CK [InstanceEdit:2132408] Weiser, JD [InstanceEdit:2133145] Weiser, JD [InstanceEdit:2266118] Weiser, JD [InstanceEdit:2266147] Weiser, JD [InstanceEdit:2454362] Weiser, JD [InstanceEdit:2455542] Weiser, JD [InstanceEdit:2587907] Weiser, JD [InstanceEdit:3132285] Weiser, JD [InstanceEdit:3445953] Weiser, JD [InstanceEdit:4341211] Weiser, JD [InstanceEdit:5083267] Weiser, JD [InstanceEdit:5263134] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689214] Cook, Justin, 2020-05-15 [InstanceEdit:9715950] Shorser, Solomon, 2021-02-17 [InstanceEdit:9730069] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750511] Weiser, JD, 2021-08-11 [InstanceEdit:9758049] Weiser, JD, 2021-11-08 [InstanceEdit:9767446] Wright, Adam, 2022-02-25 [InstanceEdit:9773560] Weiser, Joel, 2022-05-04 [InstanceEdit:9910546] Weiser, Joel, 2024-05-14 [InstanceEdit:9917761] Weiser, Joel, 2024-08-09 [InstanceEdit:9926777] Weiser, Joel, 2024-11-03 [InstanceEdit:9939260] Weiser, Joel, 2025-02-21 [InstanceEdit:9948590] Weiser, Joel, 2025-05-21 [InstanceEdit:9963890] Weiser, Joel, 2025-08-15 [InstanceEdit:9970828] Weiser, Joel, 2025-10-31 [InstanceEdit:9983368] Weiser, Joel, 2026-02-22
name	mediator complex
referenceDatabase	[ReferenceDatabase:1] GO
(hasPart)	[GO_CellularComponent:2266141] MECO complex
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No pathways have been reviewed or authored by mediator complex (25936)