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Details on Person UniProt:P0DJU7-1 PA
| Class:Id | ReferenceIsoform:2587586 |
|---|---|
| _chainChangeLog | chain:1-252 added on Sat February 7 2015 |
| _displayName | UniProt:P0DJU7-1 PA |
| _timestamp | 2026-05-15 21:14:55 |
| chain | chain:1-252 |
| checksum | E4F856AC33084766 |
| comment | FUNCTION Plays a major role in the shutoff of the host protein expression by cleaving mRNAs probably via an endonuclease activity. This host shutoff allows the virus to escape from the host antiviral response (By similarity). Hijacks host RNA splicing machinery to selectively target host RNAs containing introns for destruction. This may explain the preferential degradation of RNAs that have undergone co- or post-transcriptional processing (By similarity).SUBCELLULAR LOCATION The probable endonuclease active site in the N-terminus and the basic amino acid cluster in the C-terminus are important for the shutoff activity. The C-terminus acts as a nuclear localization signal (By similarity). The C-terminus is recruited to host protein complexes involved in nuclear Pol II RNA processing (By similarity).SIMILARITY Belongs to the influenza viruses PA-X family. |
| created | [InstanceEdit:2587579] Weiser, JD |
| description | recommendedName: Protein PA-X |
| geneName | PA |
| identifier | P0DJU7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Decay of host mRNAs by virus Eukaryotic host gene expression shutoff by virus Host cytoplasm Host gene expression shutoff by virus Host mRNA suppression by virus Host nucleus Host-virus interaction Ribosomal frameshifting |
| modified | [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9970787] Weiser, Joel, 2025-10-31 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | PA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PAX_I77A4 |
| sequenceLength | 252 |
| species | [Species:9031716] Influenza A virus |
| variantIdentifier | P0DJU7-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P0DJU7-1 PA (2587586)
