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Details on Person The activity of guanylyl cyclases is regulated by Ca2+-bindi...
| Class:Id | Summation:2586751 |
|---|---|
| _displayName | The activity of guanylyl cyclases is regulated by Ca2+-bindi... |
| _timestamp | 2013-03-26 16:57:45 |
| created | [InstanceEdit:2586753] Jassal, Bijay, 2012-11-16 |
| modified | [InstanceEdit:2754956] Jupe, S, 2012-12-10 [InstanceEdit:3229194] Jassal, Bijay, 2013-03-26 |
| text | The activity of guanylyl cyclases is regulated by Ca2+-binding, guanylyl cyclase-activating proteins (GCAPs). This regulation is the most important negative feedback mechanism triggered by Ca2+ in light. There are three GCAPs in humans; GUCA1A (Subbaraya et al. 1994), GUCA1B (Surguchov et al. 1997) and GUCA1C (Haeseleer et al. 1999). In darkness, when intracellular Ca2+ is relatively high, GCAPs suppress guanylate cyclase activity. But the light-induced fall in Ca2+ prompts Ca2+ to dissociate from GCAPs and be replaced by Mg2+, allowing the GCAPs to stimulate guanylate cyclase activity by an order of magnitude. Different GCAPs have different affinities for Ca2+. Defects in GCAP1 give rise to cone dystrophy and Lebers congenital amaurosis (https://sph.uth.edu/retnet/). |
| (summation) | [Reaction:2586748] GUCA binds Ca2+ to form GUCA:Ca2+ [Homo sapiens] |
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