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Details on Person Phosphorylation of IRAK-1 is due to three sequential phospho...
| Class:Id | Summation:2586632 |
|---|---|
| _displayName | Phosphorylation of IRAK-1 is due to three sequential phospho... |
| _timestamp | 2012-11-16 08:15:37 |
| created | [InstanceEdit:2586633] Shamovsky, V, 2012-11-16 |
| literatureReference | [LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation [LiteratureReference:450177] Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity [LiteratureReference:446867] Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 [LiteratureReference:450176] IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression |
| text | Phosphorylation of IRAK-1 is due to three sequential phosphorylation steps, which leads to full or hyper-phopshorylation of IRAK1. Under in vitro conditions these are all autophosphorylation events. First, Thr-209 is phosphorylated resulting in a conformational change of the kinase domain. Next, Thr-387 in the activation loop is phosphorylated, leading to full enzymatic activity. Several additional residues are phosphorylated in the proline-, serine-, and threonine-rich (ProST) region between the N-terminal death domain and kinase domain. Hyperphosphorylation of this region leads to dissociation of IRAK1 from the activated receptor complex. The kinase activity of IRAK1 is dispensable for IL1-induced NFkB and MAP kinase activation (Knop & Martin, 1999), unlike that of IRAK4 (Suzuki et al. 2002; Kozicak-Holbro et al. 2007), It has been suggested that IRAK1 primarily acts as an adaptor for TRAF6 (Conze et al. 2008). |
| (summation) | [Reaction:166286] Multiple IRAK1 autophosphorylation steps [Homo sapiens] |
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