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Details on Person JAK2 Phosphorylates LEPR

Class:Id	Reaction:2586553
_displayName	JAK2 Phosphorylates LEPR
_doRelease	TRUE
_timestamp	2013-10-26 10:08:57
authored	[InstanceEdit:2586547] May, B, 2012-11-15
catalystActivity	[CatalystActivity:2586554] protein tyrosine kinase activity of LEP:LEPR:p-JAK2 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2586547] May, B, 2012-11-15
edited	[InstanceEdit:2671737] May, B, 2012-11-24
inferredFrom	[Reaction:2586557] Jak2 Phosphorylates Lepr [Mus musculus]
input	[Complex:2586521] LEP:LEPR:p-JAK2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2586443] Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization [LiteratureReference:2586486] Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor [LiteratureReference:2672287] Divergent signaling capacities of the long and short isoforms of the leptin receptor [LiteratureReference:2586483] The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
modified	[InstanceEdit:2671878] May, B, 2012-11-26 [InstanceEdit:2672293] May, B, 2012-11-27 [InstanceEdit:2672317] May, B, 2012-11-27 [InstanceEdit:3110010] May, B, 2013-02-10 [InstanceEdit:3165219] May, B, 2013-02-22 [InstanceEdit:4420241] May, B, 2013-08-31 [InstanceEdit:4789069] May, B, 2013-10-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 Phosphorylates LEPR
output	[Complex:2586541] LEP:p-LEPR:p-JAK2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:2586555] JAK2 Autophosphorylates in Response to Leptin [Homo sapiens] [Reaction:2586559] Leptin Binds Leptin Receptor [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545058] R-HSA-2586553.2
summation	[Summation:2672259] Phosphorylated JAK2 phosphorylates the Leptin receptor (LEPR...
(hasEvent)	[Pathway:2586552] Signaling by Leptin [Homo sapiens]
(precedingEvent)	[Reaction:2671747] Phosphorylated LEPR Binds SHP2 (PTPN11) [Homo sapiens] [Reaction:2671855] Phosphorylated LEPR Binds STAT5 [Homo sapiens] [Reaction:2671868] Phosphorylated LEPR Binds STAT3 [Homo sapiens] [Reaction:2671872] Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 [Homo sapiens] [Reaction:2672302] Phosphorylated LEPR Binds SOCS3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786889] Update Tracker - [Reaction:2586553] JAK2 Phosphorylates LEPR - v47:[modifyText]
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No pathways have been reviewed or authored by JAK2 Phosphorylates LEPR (2586553)