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Details on Person Jak2 Autophosphorylates in Response to Leptin

Class:IdReaction:2586548
_displayNameJak2 Autophosphorylates in Response to Leptin
_doReleaseTRUE
_timestamp2017-05-13 07:37:15
authored[InstanceEdit:2586547] May, B, 2012-11-15
catalystActivity[CatalystActivity:2586549] protein tyrosine kinase activity of Lep:Lepr:Jak2 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:2586547] May, B, 2012-11-15
edited[InstanceEdit:2671737] May, B, 2012-11-24
input[Complex:2586532] Lep:Lepr:Jak2 [plasma membrane] [Mus musculus]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:873836] Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity
[LiteratureReference:2672287] Divergent signaling capacities of the long and short isoforms of the leptin receptor
modified[InstanceEdit:2671878] May, B, 2012-11-26
[InstanceEdit:2672317] May, B, 2012-11-27
[InstanceEdit:2877664] May, B, 2012-12-24
[InstanceEdit:3110010] May, B, 2013-02-10
[InstanceEdit:3165219] May, B, 2013-02-22
[InstanceEdit:4420065] May, B, 2013-08-29
[InstanceEdit:4420241] May, B, 2013-08-31
[InstanceEdit:4789069] May, B, 2013-10-26
[InstanceEdit:9006343] May, Bruce, 2017-05-13
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameJak2 Autophosphorylates in Response to Leptin
output[Complex:2586535] Lep:Lepr:p-Jak2 [plasma membrane] [Mus musculus]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:4420079] Negative regulation by 'Lep:p-Lepr:p-Jak2:Socs3 [plasma membrane]'
regulationReference[RegulationReference:9642067] Negative regulation by 'Lep:p-Lepr:p-Jak2:Socs3 [plasma membrane]' SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
releaseDate2013-09-18
reviewed[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31
[InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:4545357] R-MMU-2586548.5
summation[Summation:2672313] Upon binding leptin the leptin receptor (Lepr) changes confo...
(inferredFrom)[Reaction:2586555] JAK2 Autophosphorylates in Response to Leptin [Homo sapiens]
(precedingEvent)[Reaction:2586557] Jak2 Phosphorylates Lepr [Mus musculus]
(replacementInstances)[_Deleted:9032439] Deletion of instance: 2586551
[_Deleted:9032440] Deletion of instance: 5334727
(updatedInstance)[_UpdateTracker:9786903] Update Tracker - [Reaction:2586548] Jak2 Autophosphorylates in Response to Leptin - v47:[modifyText]
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No pathways have been reviewed or authored by Jak2 Autophosphorylates in Response to Leptin (2586548)
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