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Details on Person p-12Y-Jak2 [cytosol]

Class:Id	EntityWithAccessionedSequence:2586515
_displayName	p-12Y-Jak2 [cytosol]
_timestamp	2017-05-13 07:29:20
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2586546] May, B, 2012-11-15
endCoordinate	1129
hasModifiedResidue	[ModifiedResidue:2586510] O4'-phospho-L-tyrosine at 868 [ModifiedResidue:2586519] O4'-phospho-L-tyrosine at 966 [ModifiedResidue:2586524] O4'-phospho-L-tyrosine at 972 [ModifiedResidue:2586539] O4'-phospho-L-tyrosine at 1008 [ModifiedResidue:2671845] O4'-phospho-L-tyrosine at 813 [ModifiedResidue:9006286] O4'-phospho-L-tyrosine at 119 [ModifiedResidue:9006291] O4'-phospho-L-tyrosine at 221 [ModifiedResidue:9006296] O4'-phospho-L-tyrosine at 372 [ModifiedResidue:9006293] O4'-phospho-L-tyrosine at 373 [ModifiedResidue:9006290] O4'-phospho-L-tyrosine at 570 [ModifiedResidue:9006292] O4'-phospho-L-tyrosine at 637 [ModifiedResidue:997291] O4'-phospho-L-tyrosine at 1007
literatureReference	[LiteratureReference:873836] Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity [LiteratureReference:2671865] SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms [LiteratureReference:873860] Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity [LiteratureReference:997244] Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta [LiteratureReference:9006257] Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling [LiteratureReference:9006251] Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2 [LiteratureReference:9006243] Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state [LiteratureReference:873856] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop [LiteratureReference:873895] Determination of the transphosphorylation sites of Jak2 kinase [LiteratureReference:9006200] Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation
modified	[InstanceEdit:2671878] May, B, 2012-11-26 [InstanceEdit:9006297] May, Bruce, 2017-05-13
name	p-12Y-Jak2 Tyrosine-protein kinase JAK2 ecNumber2.7.10.2/ecNumber JAK2_MOUSE Jak2
referenceEntity	[ReferenceGeneProduct:93491] UniProt:Q62120 Jak2 [Mus musculus]
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:4546025] R-MMU-2586515.2
startCoordinate	1
(activeUnit)	[CatalystActivity:2671834] protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Sh2b1:Irs1,2 [plasma membrane] [CatalystActivity:2671842] protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Stat3 [plasma membrane] [CatalystActivity:2671849] protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Stat5 [plasma membrane] [CatalystActivity:2671861] protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Shp2 [plasma membrane] [CatalystActivity:9006328] protein tyrosine kinase activity of Epo:Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane] [CatalystActivity:9012658] protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Stat5 [plasma membrane] [CatalystActivity:9029154] protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1 [plasma membrane] [CatalystActivity:9029165] protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1 [plasma membrane]
(hasComponent)	[Complex:2586514] p-Lepr:p-Jak2 [plasma membrane] [Mus musculus] [Complex:2586525] Lepr:p-Jak2 [plasma membrane] [Mus musculus] [Complex:9006308] p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane] [Mus musculus] [Complex:9006310] Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane] [Mus musculus]
(inferredFrom)	[EntityWithAccessionedSequence:2586516] p-12Y-JAK2 [cytosol] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9897080] Update Tracker - [EntityWithAccessionedSequence:2586515] p-12Y-Jak2 [cytosol] - v61:[addHasModifiedResidue, addLiteratureReference, modifyName]
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No pathways have been reviewed or authored by p-12Y-Jak2 [cytosol] (2586515)