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Details on Person TRIF (TICAM1) was shown to induce IRF3/7 and NF-kappa-B acti...

Class:IdSummation:2584547
_displayNameTRIF (TICAM1) was shown to induce IRF3/7 and NF-kappa-B acti...
_timestamp2023-07-10 14:24:43
created[InstanceEdit:2584543] Shamovsky, V, 2012-11-14
literatureReference[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
[LiteratureReference:2423825] Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways
[LiteratureReference:177881] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
[LiteratureReference:9839730] Integrative modelling of TIR domain-containing adaptor molecule inducing interferon-β (TRIF) provides insights into its autoinhibited state
[LiteratureReference:2423829] Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
[LiteratureReference:165909] LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters
modified[InstanceEdit:3621903] Shamovsky, V, 2013-05-24
[InstanceEdit:9013877] Shamovsky, Veronica, 2017-07-26
[InstanceEdit:9839731] Shamovsky, Veronica, 2023-07-10
[InstanceEdit:9839744] Shamovsky, Veronica, 2023-07-10
textTRIF (TICAM1) was shown to induce IRF3/7 and NF-kappa-B activation as well as apoptosis through distinct intracellular signaling pathways (Yamamoto M et al., 2003; Fitzgerald KA et al., 2003; Han KJ et al., 2004; Kaiser WJ & Offermann MK 2005).

TRIF consists of an N-terminal domain (NTD) (1-153), an intermediate disordered proline-rich region, a TIR domain, and a C-terminal region (Mahita J & Sowdhamin R 2017). The disordered proline-rich region between NTD domain and the TIR domain of TICAM1 contains binding sites for TRAF (TNF receptor associated factor) family proteins, which, in turn, recruit protein kinases to promote activation of IRF3 and/or NF-kappa-B (Sato S et al., 2003; Fitzgerald KA et al., 2003). The C-terminal region of TICAM1 (TRIF) can recruit receptor-interacting serine/threonine-protein kinase 1 (RIPK1), and this event is followed by the activation of the IKK complex or the induction of programmed cell death (Han KJ et al., 2004; Kaiser WJ & Offermann MK 2005).

(summation)[Pathway:937061] TRIF (TICAM1)-mediated TLR4 signaling [Homo sapiens]
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