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Details on Person TLR3 and -4 trigger TRIF-dependent programmed cell death in ...
| Class:Id | Summation:2584546 |
|---|---|
| _displayName | TLR3 and -4 trigger TRIF-dependent programmed cell death in ... |
| _timestamp | 2015-01-21 15:22:37 |
| created | [InstanceEdit:2584543] Shamovsky, V, 2012-11-14 |
| modified | [InstanceEdit:5666085] Shamovsky, V, 2015-01-21 |
| text | TLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells (Kalai M et al. 2002; Han KJ et al. 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al. 2012; He S et al. 2011). Apoptosis is a prevalent form of programmed cell death and is mediated by the activation of a set of caspases. In addition to apoptosis, TLR3/TLR4 activation induces RIP3-dependent necroptosis. These two programmed cell-death pathways may suppress each other. When the caspase activity is impaired or inhibited, certain cell types switch the apoptotic death program to necroptosis in response to various stimuli (TNF, Fas, viral infection and other stress stimuli) (Kalai M et al. 2002; Weber A et al. 2010; Feoktistova M et al. 2011, Tenev et al 2011). |
| (summation) | [Pathway:2562578] TRIF-mediated programmed cell death [Homo sapiens] |
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No pathways have been reviewed or authored by TLR3 and -4 trigger TRIF-dependent programmed cell death in ... (2584546)
