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Details on Person UniProt:Q5VYS8 TUT7

Class:Id	ReferenceGeneProduct:257274
_chainChangeLog	chain:1-1495 added on Fri February 6 2015
_displayName	UniProt:Q5VYS8 TUT7
_timestamp	2025-08-15 22:17:36
chain	chain:1-1495
checksum	1AAB0F5B37266FF9
comment	FUNCTION Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351).CATALYTIC ACTIVITY RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphateCOFACTOR Interacts with MOV10; the interaction is RNA-dependent.INTERACTION Expression is pancytoplasmic in contrast with TUT4 expression which is enriched in cytoplasmic ribonucleoprotein granules.ALTERNATIVE PRODUCTS Utilizes two multidomain functional modules during the switch from monouridylation to oligouridylation. The catalytic module (containing the 3 CCHC-type Zinc finger domains) is essential for both activities while the Lin28-interacting module (LIM) at the N-terminal part is indispensable for oligouridylation.SIMILARITY Belongs to the DNA polymerase type-B-like family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: fullName evidence="17"Terminal uridylyltransferase 7 shortName evidence="17"TUTase 7 ecNumber evidence="6"2.7.7.52 alternativeName: Zinc finger CCHC domain-containing protein 6
geneName	TUT7 HS2 KIAA1711 ZCCHC6
identifier	Q5VYS8
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cytoplasm Magnesium Manganese Metal-binding Nucleotidyltransferase Phosphoprotein Proteomics identification Reference proteome Repeat Transferase Zinc Zinc-finger
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	TUT7
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8958275] ENSEMBL:ENSG00000083223 TUT7 [Homo sapiens]
secondaryIdentifier	TUT7_HUMAN Q5H9T0 Q5VYS5 Q5VYS7 Q658Z9 Q659A2 Q6MZJ3 Q8N5F0 Q96N57 Q96NE8 Q9C0F2 Q9H8M6
sequenceLength	1495
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:257275] UniProt:Q5VYS8-2 TUT7 [Homo sapiens] [ReferenceIsoform:257276] UniProt:Q5VYS8-3 TUT7 [Homo sapiens] [ReferenceIsoform:257277] UniProt:Q5VYS8-4 TUT7 [Homo sapiens] [ReferenceIsoform:257278] UniProt:Q5VYS8-5 TUT7 [Homo sapiens] [ReferenceIsoform:257279] UniProt:Q5VYS8-6 TUT7 [Homo sapiens] [ReferenceIsoform:407512] UniProt:Q5VYS8-1 TUT7 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:8941313] TUT7 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8957782] ZCCHC6 [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q5VYS8 TUT7 (257274)