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Details on Person UniProt:A2AA28 Mettl23
| Class:Id | ReferenceGeneProduct:256989 |
|---|---|
| _chainChangeLog | chain:1-253 added on Fri February 6 2015 |
| _displayName | UniProt:A2AA28 Mettl23 |
| _timestamp | 2025-02-21 19:29:40 |
| chain | chain:1-253 |
| checksum | EEE3B9D8F1CDB4EB |
| comment | FUNCTION Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (PubMed:28930672). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (PubMed:28930672).CATALYTIC ACTIVITY L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)SUBUNIT Interacts with HSPA5, HSP90B1, TUBULIN, UGGT1 and UGGT2 (By similarity). Interacts with TET3 (PubMed:28930672). Interacts with STPG4 (PubMed:28930672).SUBCELLULAR LOCATION Localizes in male and female zygote pronucleus and cytoplasm.TISSUE SPECIFICITY Ubiquitously expressed.DISRUPTION PHENOTYPE Mice give birth to significantly smaller litter sizes (PubMed:28930672). Moreover, about a third of the homozygous newborn mice die before weaning and only a few survive to adulthood (PubMed:28930672). Strongly reduced 5-hydroxymethylcytosine (5hmC) levels in zygotes (PubMed:28930672).SIMILARITY Belongs to the methyltransferase superfamily. METTL23 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="5"Histone-arginine methyltransferase METTL23 ecNumber evidence="3"2.1.1.319 alternativeName: fullName evidence="5"Methyltransferase-like protein 23 |
| geneName | Mettl23 |
| identifier | A2AA28 |
| isSequenceChanged | FALSE |
| keyword | Chromatin regulator Cytoplasm Developmental protein Methyltransferase Nucleus Reference proteome S-adenosyl-L-methionine Transferase |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Mettl23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MET23_MOUSE Q8R2Z2 Q9D1J5 |
| sequenceLength | 253 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9822607] Mettl23 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:A2AA28 Mettl23 (256989)
