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Details on Person UniProt:Q86XA0 METTL23
| Class:Id | ReferenceGeneProduct:256988 |
|---|---|
| _chainChangeLog | chain:1-190 added on Sat February 7 2015 |
| _displayName | UniProt:Q86XA0 METTL23 |
| _timestamp | 2025-02-21 19:29:40 |
| chain | chain:1-190 |
| checksum | 7820BDC5E7631700 |
| comment | FUNCTION Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity).CATALYTIC ACTIVITY L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)SUBUNIT Interacts with HSPA5, HSP90B1, TUBULIN, UGGT1 and UGGT2 (PubMed:23349634). Interacts with TET3 (By similarity). Interacts with STPG4 (By similarity).SUBCELLULAR LOCATION Localizes in male and female zygote pronucleus and cytoplasm.ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the methyltransferase superfamily. METTL23 family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="8"Histone-arginine methyltransferase METTL23 ecNumber evidence="1"2.1.1.319 alternativeName: fullName evidence="8"Methyltransferase-like protein 23 |
| geneName | METTL23 C17orf95 |
| identifier | Q86XA0 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chromatin regulator Cytoplasm Developmental protein Disease variant Intellectual disability Methyltransferase Nucleus Proteomics identification Reference proteome S-adenosyl-L-methionine Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | METTL23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001897] ENSEMBL:ENSG00000181038 METTL23 [Homo sapiens] |
| secondaryIdentifier | MET23_HUMAN H9ZYJ0 K7EK32 |
| sequenceLength | 190 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968382] UniProt:Q86XA0-1 METTL23 [Homo sapiens] [ReferenceIsoform:8968383] UniProt:Q86XA0-2 METTL23 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9822595] METTL23 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q86XA0 METTL23 (256988)
