Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Cytosolic iron-sulfur cluster assembly

Class:IdPathwayDiagram:2565871
_displayNameDiagram of Cytosolic iron-sulfur cluster assembly
_timestamp2025-03-12 21:12:09
created[InstanceEdit:2565872] May, B, 2012-11-08
height755
modified[InstanceEdit:2566511] May, B, 2012-11-09
[InstanceEdit:2976053] May, B, 2013-01-09
[InstanceEdit:5255114] May, B, 2014-02-06
[InstanceEdit:8855872] May, Bruce, 2016-02-07
[InstanceEdit:8952957] May, Bruce, 2016-12-20
[InstanceEdit:9942003] D'Eustachio, Peter, 2025-03-12
representedPathway[Pathway:2564830] Cytosolic iron-sulfur cluster assembly [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="35" reactomeDiagramId="2565871"> <Properties> <displayName>Diagram of Cytosolic iron-sulfur cluster assembly</displayName> </Properties> <Nodes> <org.gk.render.RenderableEntitySet id="4" reactomeId="2564793" position="384 500" bounds="322 482 124 37" textPosition="322 482"> <Properties> <displayName>Apoprotein Lacking 4Fe-4S Cluster</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="5" reactomeId="2564791" position="384 684" bounds="325 659 119 51" textPosition="325 659" bgColor="204 255 255"> <Properties> <displayName>Holoprotein Containing 4Fe-4S Cluster</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="6" reactomeId="2564767" position="659 197" bounds="635 186 48 23" textPosition="635 186"> <Properties> <displayName>NUBP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="7" reactomeId="2564814" position="420 587" bounds="369 569 102 37" textPosition="369 570" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NARFL:CIAO1:FAM96B:MMS19</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="8" reactomeId="2564799" position="741 258" bounds="694 247 94 23" textPosition="694 248" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NUBP1:4Fe-4S</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="11" reactomeId="29364" position="173 269" bounds="144 254 59 31" textPosition="148 258"> <Properties> <displayName>NADPH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="12" reactomeId="2564798" position="542 429" bounds="493 411 98 37" textPosition="493 412" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NUBP2:4Fe-4S:NUBP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="13" reactomeId="2564804" position="329 270" bounds="276 252 106 37" textPosition="276 253" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NDOR1:CIAPIN1 oxidized</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="14" reactomeId="29366" position="173 389" bounds="143 374 60 31" textPosition="147 378"> <Properties> <displayName>NADP+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="15" reactomeId="2564805" position="398 360" bounds="345 342 106 37" textPosition="345 343" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NDOR1:CIAPIN1 reduced</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="19" reactomeId="70106" position="257 415" bounds="239 400 36 31" textPosition="243 404"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="20" reactomeId="1369041" position="398 146" bounds="359 135 78 23" textPosition="359 136" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABC7 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="22" reactomeId="71160" position="537 271" bounds="522 257 31 28" textPosition="527 260"> <Properties> <displayName>Fe</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="23" reactomeId="2566513" position="555 223" bounds="542 210 26 27" textPosition="548 212"> <Properties> <displayName>S</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="24" reactomeId="70101" position="454 375" bounds="6 4 896 743" textPosition="34 678" bgColor="250 240 240" lineColor="255 153 102" insets="16 15 873 715"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="16" /> <Component id="4" /> <Component id="5" /> <Component id="6" /> <Component id="7" /> <Component id="8" /> <Component id="12" /> <Component id="14" /> <Component id="15" /> <Component id="19" /> <Component id="22" /> <Component id="23" /> <Component id="10" /> <Component id="17" /> <Component id="11" /> <Component id="28" /> <Component id="13" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="25" reactomeId="5460" position="335 106" bounds="210 50 251 112" textPosition="223 98" bgColor="250 240 240" lineColor="255 153 102" insets="220 63 229 71"> <Properties> <displayName>mitochondrial matrix</displayName> </Properties> <Components> <Component id="20" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="28" reactomeId="17927" position="314 118" bounds="153 32 322 173" textPosition="162 162" bgColor="250 240 240" lineColor="255 153 102" insets="159 42 312 156"> <Properties> <displayName>mitochondrial intermembrane space</displayName> </Properties> <Components> <Component id="25" /> </Components> </org.gk.render.RenderableCompartment> </Nodes> <Edges> <org.gk.render.RenderableReaction id="10" reactomeId="2564828" points="542 535, 543 586, 543 630" position="543 586" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="12" points="542 451" /> <Input id="4" points="452 513" /> </Inputs> <Outputs> <Output id="6" stoichiometry="2" points="686 197, 816 199, 826 668" /> <Output id="8" stoichiometry="2" points="741 273, 747 626" /> <Output id="5" points="450 663" /> </Outputs> <Catalysts> <Catalyst id="7" points="474 586" /> </Catalysts> <Properties> <displayName>CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16" reactomeId="2564824" points="255 307, 255 332, 255 358" position="255 332" lineWidth="1.0"> <Inputs> <Input id="11" points="206 282" /> <Input id="13" points="292 292" /> </Inputs> <Outputs> <Output id="14" points="206 377" /> <Output id="15" points="342 359" /> <Output id="19" points="256 397" /> </Outputs> <Catalysts> <Catalyst id="13" points="321 292, 305 331" /> </Catalysts> <Properties> <displayName>NADPH reduces NDOR1:CIAPIN1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="2564826" points="632 288, 540 359, 541 408" position="540 359" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="8" stoichiometry="2" points="699 273" /> <Input id="22" stoichiometry="4" points="556 273" /> <Input id="6" stoichiometry="2" points="655 212" /> <Input id="23" stoichiometry="4" points="571 233" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Catalysts> <Catalyst id="15" points="454 359" /> </Catalysts> <Activators> <Activator id="20" points="405 161" /> </Activators> <Properties> <displayName>4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width910
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Cytosolic iron-sulfur cluster assembly (2565871)
Follow Reactome