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Details on Person Caspase-8 processing within TLR4 complex

Class:Id	Reaction:2562564
_displayName	Caspase-8 processing within TLR4 complex
_doRelease	TRUE
_timestamp	2017-07-26 05:35:12
authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
catalystActivity	[CatalystActivity:2562582] cysteine-type endopeptidase activity of activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
goBiologicalProcess	[GO_BiologicalProcess:2133497] apoptotic signaling pathway
input	[Complex:2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1267800] Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms [LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:2584548] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [LiteratureReference:1267836] Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation [LiteratureReference:2584573] Insights into the regulatory mechanism for caspase-8 activation
modified	[InstanceEdit:2569084] Shamovsky, V, 2012-11-12 [InstanceEdit:2581444] Shamovsky, V, 2012-11-13 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2584572] Shamovsky, V, 2012-11-14 [InstanceEdit:2627686] Shamovsky, V, 2012-11-19 [InstanceEdit:2629677] Shamovsky, V, 2012-11-20 [InstanceEdit:2632484] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:5340157] Shamovsky, V, 2014-03-10 [InstanceEdit:9013815] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-8 processing within TLR4 complex
output	[Complex:2562550] active caspase-8 [cytosol] [Homo sapiens] [Complex:2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:2562541] TLR4-induced ripoptosome assembly [Homo sapiens] [Reaction:168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200725] R-HSA-2562564.3
summation	[Summation:2584545] TLR4 and TLR3 signaling pathways were shown to mediate apopt...
(hasEvent)	[Pathway:140534] Caspase activation via Death Receptors in the presence of ligand [Homo sapiens] [Pathway:2562578] TRIF-mediated programmed cell death [Homo sapiens]
(precedingEvent)	[Reaction:201637] Caspase-mediated cleavage of plectin-1 [Homo sapiens] [Reaction:350319] Caspase mediated cleavage of vimentin at IDVD (259) [Homo sapiens] [Reaction:351863] Translocation of active caspase-8 to the mitochondrial membrane [Homo sapiens] [BlackBoxEvent:5357966] CASP3 is cleaved by CASP8 [Homo sapiens] [BlackBoxEvent:9757951] CASP8 cleaves N4BP1 at D424, D490 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780623] Update Tracker - [Reaction:2562564] Caspase-8 processing within TLR4 complex - v62:[modifyText, removeLiteratureReference]
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