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Details on Person active caspase-8 [cytosol]

Class:Id	Complex:2562550
_displayName	active caspase-8 [cytosol]
_timestamp	2013-02-28 11:53:14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
hasComponent	[Complex:139950] Caspase-8 dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:75975] CASP8(217-374) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:76158] CASP8(385-479) [cytosol] [Homo sapiens] [Complex:139950] Caspase-8 dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:75975] CASP8(217-374) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:76158] CASP8(385-479) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2562575] The atomic-resolution structure of human caspase-8, a key activator of apoptosis [LiteratureReference:2562554] The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis
name	active caspase-8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3203992] R-HSA-2562550.1
(hasComponent)	[Complex:2672221] active caspase-8:viral CRMA/SPI-2 [cytosol] [Homo sapiens]
(input)	[Reaction:351863] Translocation of active caspase-8 to the mitochondrial membrane [Homo sapiens] [Reaction:2672196] Viral serpin blocks caspase-8 activity [Homo sapiens]
(output)	[BlackBoxEvent:139952] Caspase-8 processing in the DISC [Homo sapiens] [Reaction:2562564] Caspase-8 processing within TLR4 complex [Homo sapiens] [Reaction:9013895] Caspase-8 processing within TLR3 complex [Homo sapiens]
(physicalEntity)	[CatalystActivity:139951] cysteine-type endopeptidase activity of active caspase-8 [cytosol] [CatalystActivity:9757965] cysteine-type peptidase activity of active caspase-8 [cytosol]
(regulator)	[NegativeRegulation:6793053] Negative regulation by 'active caspase-8 [cytosol]' [NegativeRegulation:9757966] Negative regulation by 'active caspase-8 [cytosol]'
(requiredInputComponent)	[BlackBoxEvent:5357828] RIPK1 is cleaved by CASP8 [Homo sapiens] [BlackBoxEvent:9686930] RIPK3 is cleaved by CASP8 [Homo sapiens] [FailedReaction:9693929] RIPK1 variant is not cleaved by CASP8 [Homo sapiens] [BlackBoxEvent:9697750] RIPK1 is cleaved by CASP8:FLIP(L) [Homo sapiens]
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No pathways have been reviewed or authored by active caspase-8 [cytosol] (2562550)