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Details on Person activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

Class:IdComplex:2562542
_displayNameactivated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
_timestamp2017-07-26 05:57:10
compartment[Compartment:74700] endosome membrane
created[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
hasComponent
literatureReference[LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
[LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
modified[InstanceEdit:9013881] Shamovsky, Veronica, 2017-07-26
nameactivated TLR4:TRIF:RIP1:FADD:pro-caspase-8
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3202719] R-HSA-2562542.2
(input)[Reaction:2562564] Caspase-8 processing within TLR4 complex [Homo sapiens]
(output)[Reaction:2562541] TLR4-induced ripoptosome assembly [Homo sapiens]
(physicalEntity)[CatalystActivity:2562582] cysteine-type endopeptidase activity of activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
(updatedInstance)[_UpdateTracker:9891937] Update Tracker - [Complex:2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - v52:[updateContainedComponent]
[_UpdateTracker:9892668] Update Tracker - [Complex:2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - v54:[updateContainedComponent]
[_UpdateTracker:9897406] Update Tracker - [Complex:2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - v62:[add_removeHasComponent, modifyName, removeLiteratureReference]
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No pathways have been reviewed or authored by activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (2562542)
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