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Details on Person TLR4-induced ripoptosome assembly

Class:Id	Reaction:2562541
_displayName	TLR4-induced ripoptosome assembly
_doRelease	TRUE
_timestamp	2017-07-26 05:51:46
authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
input	[Complex:168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:57031] CASP8(1-479) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:57031] CASP8(1-479) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:54639] FADD [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:54639] FADD [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:448684] Caspase-activation pathways in apoptosis and immunity [LiteratureReference:2423825] Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms [LiteratureReference:2584562] The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
modified	[InstanceEdit:2581444] Shamovsky, V, 2012-11-13 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2584572] Shamovsky, V, 2012-11-14 [InstanceEdit:2627686] Shamovsky, V, 2012-11-19 [InstanceEdit:2629677] Shamovsky, V, 2012-11-20 [InstanceEdit:2632486] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:9013874] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR4-induced ripoptosome assembly
output	[Complex:2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Homo sapiens] [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) [Homo sapiens]
regulatedBy	[NegativeRegulation:2569044] Negative regulation by 'K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
releaseDate	2012-12-04
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200317] R-HSA-2562541.4
summation	[Summation:2584544] TRIF was repored to efficiently induce apoptosis when overex...
(hasEvent)	[Pathway:2562578] TRIF-mediated programmed cell death [Homo sapiens]
(precedingEvent)	[Reaction:2562564] Caspase-8 processing within TLR4 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780762] Update Tracker - [Reaction:2562541] TLR4-induced ripoptosome assembly - v62:[modifyText, removeLiteratureReference] [_UpdateTracker:9786298] Update Tracker - [Reaction:2562541] TLR4-induced ripoptosome assembly - v50:[add_removeRegulator]
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No pathways have been reviewed or authored by TLR4-induced ripoptosome assembly (2562541)