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Details on Person TLR1/2 ligand binds to CD14

Class:Id	Reaction:2559468
_displayName	TLR1/2 ligand binds to CD14
_doRelease	TRUE
_timestamp	2014-08-29 16:40:16
authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2559467] Shamovsky, V, 2012-11-02
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
input	[DefinedSet:168944] TLR1:TLR2 recognized ligand [extracellular region] [Neisseria meningitidis serogroup B] [EntityWithAccessionedSequence:166033] GPIN-CD14(20-345) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:2559436] Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1 [LiteratureReference:2428886] Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting
modified	[InstanceEdit:2581444] Shamovsky, V, 2012-11-13 [InstanceEdit:2627686] Shamovsky, V, 2012-11-19 [InstanceEdit:2629677] Shamovsky, V, 2012-11-20 [InstanceEdit:5621483] Shamovsky, V, 2014-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR1/2 ligand binds to CD14
output	[Complex:2559462] TLR1:TLR2 ligand:CD14 [plasma membrane] [Homo sapiens]
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2012-12-04
reviewed	[InstanceEdit:2581520] Granucci, Francesca, Zanoni, Ivan, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200561] R-HSA-2559468.2
summation	[Summation:2559443] CD14, a GPI-anchored molecule found on the cell surface of h...
(hasEvent)	[Pathway:168179] Toll Like Receptor TLR1:TLR2 Cascade [Homo sapiens]
(precedingEvent)	[Reaction:168951] TLR1:TLR2 is recruited to ligand:CD14 [Homo sapiens]
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No pathways have been reviewed or authored by TLR1/2 ligand binds to CD14 (2559468)