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Details on Person CD14:LPS binds CR3

Class:Id	Reaction:2559439
_displayName	CD14:LPS binds CR3
_doRelease	TRUE
_timestamp	2013-02-28 10:58:45
authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2559420] Shamovsky, V, 2012-11-02
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
input	[DefinedSet:166043] LPS:CD14 [extracellular region] [Homo sapiens] [Complex:202755] Integrin alphaMbeta2 [plasma membrane] [Homo sapiens] [Complex:202755] Integrin alphaMbeta2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2559434] CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide [LiteratureReference:2559417] Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide [LiteratureReference:2559432] Lipopolysaccharide-coated erythrocytes activate human neutrophils via CD14 while subsequent binding is through CD11b/CD18 [LiteratureReference:2559437] Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
modified	[InstanceEdit:2581445] Shamovsky, V, 2012-11-13 [InstanceEdit:2581523] Shamovsky, V, 2012-11-13 [InstanceEdit:2586587] Shamovsky, V, 2012-11-15 [InstanceEdit:2629677] Shamovsky, V, 2012-11-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CD14:LPS binds CR3
output	[Complex:2559438] LPS:CD14:CR3 [plasma membrane] [Homo sapiens] [Complex:2559438] LPS:CD14:CR3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:166038] GPI-bound CD14 binds LPS [Homo sapiens] [Reaction:166015] Association of LBP with LPS [Homo sapiens] [Reaction:169719] Secreted CD14 binds LPS [Homo sapiens] [Reaction:166015] Association of LBP with LPS [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2581520] Granucci, Francesca, Zanoni, Ivan, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200621] R-HSA-2559439.2
summation	[Summation:2559435] Upon LPS stimulation, CD14, in addition to promote endotoxin...
(hasEvent)	[Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade [Homo sapiens]
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No pathways have been reviewed or authored by CD14:LPS binds CR3 (2559439)