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Details on Person UniProt:O95619 YEATS4
| Class:Id | ReferenceGeneProduct:255602 |
|---|---|
| _chainChangeLog | chain:1-227 added on Sat February 7 2015 |
| _displayName | UniProt:O95619 YEATS4 |
| _timestamp | 2024-11-03 20:12:50 |
| chain | chain:1-227 |
| checksum | 34C4692B227A7B85 |
| comment | FUNCTION Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:29900004, PubMed:30071723). Also able to recognize and bind crotonylated histone H3 (PubMed:30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed:29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed:29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).SUBUNIT Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity (PubMed:12963728, PubMed:14966270). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (PubMed:12963728, PubMed:14966270). The NuA4 complex interacts with MYC and the adenovirus E1A protein (PubMed:12963728, PubMed:14966270). Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41 (PubMed:14966270, PubMed:29437725). Interacts with MLLT10/AF10 (PubMed:11756182). Also interacts with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1 (PubMed:10913114, PubMed:11756182, PubMed:11903063, PubMed:12620397).INTERACTION Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.DOMAIN The YEATS domain specifically recognizes and binds acylated histones, with a preference for histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac).CAUTION According to a report, recognizes and binds histone H3 succinylated at 'Lys-122' (H3K122succ) (PubMed:29463709). However, another report only observed poor binding with succinylated histone H3 (PubMed:30071723). |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="16"YEATS domain-containing protein 4 alternativeName: fullName evidence="15"Glioma-amplified sequence 41 shortName evidence="15"Gas41 alternativeName: NuMA-binding protein 1 shortName: NuBI-1 shortName: NuBI1 |
| geneName | YEATS4 GAS41 |
| identifier | O95619 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chromatin regulator Coiled coil Direct protein sequencing Growth regulation Isopeptide bond Nucleus Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | YEATS4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988768] ENSEMBL:ENSG00000127337 YEATS4 [Homo sapiens] |
| secondaryIdentifier | YETS4_HUMAN Q9NQD0 |
| sequenceLength | 227 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:3322940] YEATS4 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95619 YEATS4 (255602)
