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Details on Person UniProt:Q8IWG1 DNAI3
| Class:Id | ReferenceGeneProduct:254644 |
|---|---|
| _chainChangeLog | chain:1-891 added on Fri February 6 2015 |
| _displayName | UniProt:Q8IWG1 DNAI3 |
| _timestamp | 2024-11-03 20:05:04 |
| chain | chain:1-891 |
| checksum | 982EA7B814BCC1F1 |
| comment | FUNCTION Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (PubMed:32128961). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (By similarity). May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (By similarity).SUBUNIT Interacts with ACTR2; this interaction reduces binding of the Arp2/3 complex to the VCA domain of nucleation promoting factors (PubMed:32128961). Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Found in a associated with the catalytic heavy chain DNAH2, the intermediate chain DNAI4, and the light chain DYNLT1 (By similarity).SUBCELLULAR LOCATION Up-regulated at the transcriptional level by TP53.DISEASE A rare heterozygous in-frame DNAI3 deletion encompassing exons 14-17 has been found in a fetus with encephalocele. Overexpression of human DNAI3 RNA lacking exons 14-17 in zebrafish embryos also results in similar brain malformations, suggesting that DNAI3 defects might be involved in encephalocele formation. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="7"Dynein axonemal intermediate chain 3 alternativeName: Testis development protein NYD-SP29 alternativeName: WD repeat-containing protein 63 |
| geneName | DNAI3 WDR63 |
| identifier | Q8IWG1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Coiled coil Cytoplasm Proteomics identification Reference proteome Repeat WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DNAI3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988211] ENSEMBL:ENSG00000162643 DNAI3 [Homo sapiens] |
| secondaryIdentifier | DNAI3_HUMAN A8K988 Q96L72 Q96NU4 |
| sequenceLength | 891 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:254645] UniProt:Q8IWG1-2 DNAI3 [Homo sapiens] [ReferenceIsoform:410845] UniProt:Q8IWG1-1 DNAI3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9966700] DNAI3 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969257] DNAI3 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IWG1 DNAI3 (254644)
