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Details on Person UniProt:Q96DI7 SNRNP40
| Class:Id | ReferenceGeneProduct:254615 |
|---|---|
| _chainChangeLog | chain:1-357 added on Fri February 6 2015 |
| _displayName | UniProt:Q96DI7 SNRNP40 |
| _timestamp | 2024-11-03 20:16:45 |
| chain | chain:1-357 |
| checksum | DE8CADEB098E560C |
| comment | FUNCTION Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:30315277, PubMed:30705154). Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome (PubMed:16723661, PubMed:26912367, PubMed:9774689). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).SUBUNIT Component of the pre-catalytic and catalytic spliceosome complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:30315277, PubMed:9731529). Component of the postcatalytic spliceosome P complex (PubMed:30705154). Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:16723661). Component of the minor spliceosome, which splices U12-type introns (PubMed:33509932).INTERACTION An insertion/deletion of a short nucleotide stretch in its cDNA resulting in a frameshift. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: U5 small nuclear ribonucleoprotein 40 kDa protein shortName: U5 snRNP 40 kDa protein shortName: U5-40K alternativeName: 38 kDa-splicing factor alternativeName: Prp8-binding protein shortName: hPRP8BP alternativeName: U5 snRNP-specific 40 kDa protein alternativeName: WD repeat-containing protein 57 |
| geneName | SNRNP40 PRP8BP SFP38 WDR57 |
| identifier | Q96DI7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Isopeptide bond Methylation mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Repeat Spliceosome Ubl conjugation WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SNRNP40 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004980] ENSEMBL:ENSG00000060688 SNRNP40 [Homo sapiens] |
| secondaryIdentifier | SNR40_HUMAN B4DQJ1 O75938 O95320 |
| sequenceLength | 357 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968984] UniProt:Q96DI7-1 SNRNP40 [Homo sapiens] [ReferenceIsoform:8968985] UniProt:Q96DI7-2 SNRNP40 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71877] SNRNP40 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96DI7 SNRNP40 (254615)
