Query author contributions in Reactome
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Details on Person Histone deacetylase HDAC8 deacetylates SMC3 cohesin subunit....
| Class:Id | Summation:2545246 |
|---|---|
| _displayName | Histone deacetylase HDAC8 deacetylates SMC3 cohesin subunit.... |
| _timestamp | 2012-11-01 15:46:56 |
| created | [InstanceEdit:2545216] Orlic-Milacic, M, 2012-11-01 |
| literatureReference | [LiteratureReference:2545212] HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle |
| text | Histone deacetylase HDAC8 deacetylates SMC3 cohesin subunit. SMC3 deacetylation promotes dissociation of cleaved RAD21 fragments from other cohesin proteins and their replacement with intact RAD21, thereby allowing restoration of the cohesin complex (Deardorff et al. 2012). HDAC8 mutations, as well as mutations in NIPBL, SMC1A and SMC3, can cause Cornelia de Lang syndrome (Deardorff et al. 2012). |
| (summation) | [Reaction:2545203] Deacetylation of cleaved cohesin [Homo sapiens] |
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No pathways have been reviewed or authored by Histone deacetylase HDAC8 deacetylates SMC3 cohesin subunit.... (2545246)
