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Details on Person UniProt:Q7Z5K2 WAPL
| Class:Id | ReferenceGeneProduct:254475 |
|---|---|
| _chainChangeLog | chain:1-1190 added on Sat February 7 2015 |
| _displayName | UniProt:Q7Z5K2 WAPL |
| _timestamp | 2024-11-03 19:54:39 |
| chain | chain:1-1190 |
| checksum | A01026E520BFAB2F |
| comment | FUNCTION Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.SUBUNIT Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the interaction is direct, cohesin-dependent and competitive with CDCA5/SORORIN. Interacts (via FGF motifs) with PDS5B; the interaction is direct. Interacts with a SMC1 protein (SMC1A or SMC1B) and SMC3.SUBUNIT (Microbial infection) Isoform 2 interacts with Epstein-Barr virus EBNA2.INTERACTION Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.ALTERNATIVE PRODUCTS Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.PTM Deubiquitinated by USP37; leading to stabilization.SIMILARITY Belongs to the WAPL family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Wings apart-like protein homolog alternativeName: Friend of EBNA2 protein alternativeName: fullName evidence="17"WAPL cohesin release factor |
| geneName | WAPL FOE KIAA0261 WAPAL |
| identifier | Q7Z5K2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Chromosome Coiled coil Cytoplasm Host-virus interaction Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | WAPL |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003917] ENSEMBL:ENSG00000062650 WAPL [Homo sapiens] |
| secondaryIdentifier | WAPL_HUMAN A7E2B5 Q5VSK5 Q8IX10 Q92549 |
| sequenceLength | 1190 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:254476] UniProt:Q7Z5K2-2 WAPL [Homo sapiens] [ReferenceIsoform:254477] UniProt:Q7Z5K2-3 WAPL [Homo sapiens] [ReferenceIsoform:409477] UniProt:Q7Z5K2-1 WAPL [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2466355] WAPAL [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2484802] WAPAL [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2577088] WAPAL [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:2577090] WAPAL [chromosome] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q7Z5K2 WAPL (254475)
