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Details on Person UniProt:Q8N1B4 VPS52
| Class:Id | ReferenceGeneProduct:254357 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-723 added on Fri February 6 2015;initiator methionine:1 for 254357 removed on Fri Nov 03 2023;initiator methionine: for 254357 added on Fri Nov 03 2023;initiator methionine: for 254357 removed on Fri Aug 15 2025;initiator methionine:1 for 254357 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8N1B4 VPS52 |
| _timestamp | 2025-08-15 21:35:18 |
| chain | initiator methionine:1 chain:2-723 |
| checksum | C0961E2BE50B24DF |
| comment | FUNCTION Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).SUBUNIT Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:15878329, PubMed:20685960, PubMed:27440922). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (PubMed:25799061, PubMed:27440922). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (PubMed:27440922). Interacts with RAB6A and STX10 (PubMed:15878329, PubMed:20685960). Interacts with BLTP3B (PubMed:20163565).INTERACTION Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061).ALTERNATIVE PRODUCTS Belongs to the VPS52 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Vacuolar protein sorting-associated protein 52 homolog alternativeName: SAC2 suppressor of actin mutations 2-like protein |
| geneName | VPS52 SACM2L |
| identifier | Q8N1B4 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Coiled coil Endosome Golgi apparatus Membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | VPS52 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992823] ENSEMBL:ENSG00000223501 VPS52 [Homo sapiens] |
| secondaryIdentifier | VPS52_HUMAN A2BF38 B0UZZ4 B4DNI9 Q53GR4 Q5JPA0 Q5SQW1 Q8IUN6 Q9NPT5 |
| sequenceLength | 723 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968615] UniProt:Q8N1B4-1 VPS52 [Homo sapiens] [ReferenceIsoform:8968616] UniProt:Q8N1B4-2 VPS52 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6811029] VPS52 [trans-Golgi network membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8N1B4 VPS52 (254357)
