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Details on Person UniProt:Q96IX5 ATP5MK
| Class:Id | ReferenceGeneProduct:253961 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-58 added on Fri February 6 2015;initiator methionine:1 for 253961 removed on Fri Nov 03 2023;initiator methionine: for 253961 added on Fri Nov 03 2023;initiator methionine: for 253961 removed on Fri Aug 15 2025;initiator methionine:1 for 253961 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q96IX5 ATP5MK |
| _timestamp | 2026-02-20 23:03:24 |
| chain | initiator methionine:1 chain:2-58 |
| checksum | 3BFC4C9E2920B126 |
| comment | FUNCTION Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (By similarity). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (By similarity). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (PubMed:21345788, PubMed:29917077).SUBUNIT Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP (By similarity). ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j) (By similarity). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP) (By similarity). The ATP synthase complex/complex V exists as a monomeric and a dimeric supercomplex that helps shape mitochondrial cristae to optimize proton flow (PubMed:29917077).SUBCELLULAR LOCATION Transactivated by SBP1.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="8"ATP synthase F(0) complex subunit k, mitochondrial alternativeName: fullName evidence="8"ATP synthase membrane subunit DAPIT, mitochondrial alternativeName: Diabetes-associated protein in insulin-sensitive tissues alternativeName: HCV F-transactivated protein 2 alternativeName: fullName evidence="8"Up-regulated during skeletal muscle growth protein 5 |
| geneName | ATP5MK ATP5MD DAPIT HCVFTP2 USMG5 PD04912 |
| identifier | Q96IX5 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Membrane Mitochondrion Primary mitochondrial disease Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ATP5MK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9005052] ENSEMBL:ENSG00000173915 ATP5MK [Homo sapiens] |
| secondaryIdentifier | ATPMK_HUMAN B2R4N2 D3DR92 |
| sequenceLength | 58 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9864451] ATP5MK [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96IX5 ATP5MK (253961)
