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Details on Person UniProt:Q70EL4 USP43
| Class:Id | ReferenceGeneProduct:253621 |
|---|---|
| _chainChangeLog | chain:1-1123 added on Fri February 6 2015 |
| _displayName | UniProt:Q70EL4 USP43 |
| _timestamp | 2024-11-03 20:08:21 |
| chain | chain:1-1123 |
| checksum | 3B4FE86EC619173C |
| comment | FUNCTION May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).CATALYTIC ACTIVITY Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ALTERNATIVE PRODUCTS Expressed in brain, aorta and lung at low levels.SIMILARITY Belongs to the peptidase C19 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Ubiquitin carboxyl-terminal hydrolase 43 ecNumber: 3.4.19.12 alternativeName: Deubiquitinating enzyme 43 alternativeName: Ubiquitin thioesterase 43 alternativeName: Ubiquitin-specific-processing protease 43 |
| geneName | USP43 |
| identifier | Q70EL4 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Hydrolase Methylation Phosphoprotein Protease Proteomics identification Reference proteome Thiol protease Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | USP43 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998081] ENSEMBL:ENSG00000154914 USP43 [Homo sapiens] |
| secondaryIdentifier | UBP43_HUMAN A6NDT9 B7ZLT9 B7ZVX5 Q8N2C5 Q96DQ6 |
| sequenceLength | 1123 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:253622] UniProt:Q70EL4-2 USP43 [Homo sapiens] [ReferenceIsoform:253623] UniProt:Q70EL4-3 USP43 [Homo sapiens] [ReferenceIsoform:409041] UniProt:Q70EL4-1 USP43 [Homo sapiens] [ReferenceIsoform:8966348] UniProt:Q70EL4-4 USP43 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5653784] USP43 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q70EL4 USP43 (253621)
